| Literature DB >> 18550373 |
Tony Siu1, Yiwei Li, Johnny Nagasawa, Jun Liang, Lida Tehrani, Peter Chua, Raymond E Jones, Deborah Defeo-Jones, Stanley F Barnett, Ronald G Robinson.
Abstract
This letter details the attenuation of hERG in a class of Akt inhibitors through heteroatom insertions into aromatic rings. The development of a cell-active dual Akt 1 and 2 inhibitors devoid of hERG activity is discussed using structure-activity relationships.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18550373 DOI： 10.1016/j.bmcl.2008.05.084
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823