| Literature DB >> 18550273 |
Jens Strelau1, Corina Schmeer, Heike Peterziel, Tina Sackmann, Christel Herold-Mende, Hans Steiner, Michael Weller, Klaus Unsicker.
Abstract
Recent studies have demonstrated growth-inhibiting effects of growth differentiation factor-15 (GDF-15) on different cancer cell lines invitro and on tumor growth in vivo. Here, we present data concerning expression of GDF-15 in glioblastoma. We found low levels of GDF-15 transcripts in primary glioblastoma. Thus, GDF-15 expression might be exploited as a useful indicator for distinguishing primary from other glial derived tumors. In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.Entities:
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Year: 2008 PMID： 18550273 DOI： 10.1016/j.canlet.2008.04.042
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679