| Literature DB >> 18549235 |
Yoichiro Kuninobu1, Mitsumi Nishi, Salprima Yudha S, Kazuhiko Takai.
Abstract
Treatment of beta-keto esters with terminal acetylenes in the presence of a catalytic amount of a manganese complex, MnBr(CO)5, and molecular sieves, gave multisubstituted aromatic compounds in good to excellent yields. This reaction employs [2 + 2 + 2] cycloaddition of beta-keto esters and 2 equiv of terminal acetylenes with dehydration. In the case of a 1,3-diketone, the corresponding acetophenone derivative and its deacylated compound can be synthesized selectively.Entities:
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Year: 2008 PMID： 18549235 DOI： 10.1021/ol800969h
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005