| Literature DB >> 18549203 |
Emilie Genin1, Olivier Carion, Benoit Mahler, Benoit Dubertret, Nathalie Arhel, Pierre Charneau, Eric Doris, Charles Mioskowski.
Abstract
Smart nanohybrids were prepared by conjugation of CrAsH to hydrosoluble and biocompatible quantum dots (QDs). The resulting probes were shown to bind efficiently and selectively to Cys-tagged proteins. The interaction with the protein was detected by an increase of the fluorescence emission of CrAsH. While the latter faded rapidly under continuous excitation, emission of the QD remained unaffected. The persistent fluorescence of the QD should thus allow extended monitoring of the target protein.Entities:
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Year: 2008 PMID： 18549203 DOI： 10.1021/ja802987q
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419