BACKGROUND: Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics. OBJECTIVE: To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex. DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized as having or not having a sibling with OSAS, based on the presence or absence of the disorder in at least 1 of their siblings. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for men and women with a sibling with OSAS, compared with men and women in the reference group (SIR = 1). RESULTS: After accounting for socioeconomic status, age, geographic region, and period of diagnosis, men with at least 1 sibling who had OSAS had a SIR of 3.42 (95% CI, 2.18-5.36); the corresponding SIR in women was 3.25 (95% CI, 1.84-5.65). CONCLUSIONS: Our results indicate that physicians should consider family history of OSAS when deciding whether to refer a patient for further sleep examinations.
BACKGROUND: Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics. OBJECTIVE: To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex. DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized as having or not having a sibling with OSAS, based on the presence or absence of the disorder in at least 1 of their siblings. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for men and women with a sibling with OSAS, compared with men and women in the reference group (SIR = 1). RESULTS: After accounting for socioeconomic status, age, geographic region, and period of diagnosis, men with at least 1 sibling who had OSAS had a SIR of 3.42 (95% CI, 2.18-5.36); the corresponding SIR in women was 3.25 (95% CI, 1.84-5.65). CONCLUSIONS: Our results indicate that physicians should consider family history of OSAS when deciding whether to refer a patient for further sleep examinations.
Authors: Richard J Schwab; Michael Pasirstein; Robert Pierson; Adonna Mackley; Robert Hachadoorian; Raanan Arens; Greg Maislin; Allan I Pack Journal: Am J Respir Crit Care Med Date: 2003-05-13 Impact factor: 21.405
Authors: Chun Ting Au; Jihui Zhang; Jennifa Yuk Fa Cheung; Kate Ching Ching Chan; Yun Kwok Wing; Albert M Li Journal: J Clin Sleep Med Date: 2019-11-15 Impact factor: 4.062
Authors: Lamia H Ibrahim; Frank J Jacono; Sanjay R Patel; Robert J Thomas; Emma K Larkin; Joseph E Mietus; Chung-Kang Peng; Ary L Goldberger; Susan Redline Journal: Sleep Date: 2010-05 Impact factor: 5.849