Literature DB >> 185484

Inhibition of actions of glucagon in adipocytes by gastric inhibitory polypeptide.

J Dupre, N Greenidge, T J McDonald, S A Ross, D Rubinstein.   

Abstract

Possible interactions between gastric inhibitory polypeptide (GIP) and glucagon were investigated in rat adipocytes. GIP was nonlipolytic and inhibited lipolysis stimulated by glucagon but not that stimulated by secretin or vasoactive intestinal polypeptide (VIP). GIP competed with 125I-glucagon for binding to adipocyte receptors, and at physiologic concentrations inhibited the stimulation of AMP produced by glucagon. Thus GIP acts as an inhibitor of actions of glucagon on adipocytes and may be a physiologic modulator of effects of glucagon.

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Year:  1976        PMID： 185484     DOI： 10.1016/s0026-0495(76)80002-9

Source DB:  PubMed          Journal:  Metabolism        ISSN： 0026-0495            Impact factor:   8.694


  9 in total

1.  Enhancement of insulin action after oral glucose ingestion.

Authors:  W J Kingston; J N Livingston; R T Moxley
Journal:  J Clin Invest       Date:  1986-04       Impact factor: 14.808

2.  Insulin-dependent inhibition of hepatic glycogenolysis by gastric inhibitory polypeptide (GIP) in perfused rat liver.

Authors:  H Hartmann; R Ebert; W Creutzfeldt
Journal:  Diabetologia       Date:  1986-02       Impact factor: 10.122

Review 3.  New developments in the incretin concept.

Authors:  W Creutzfeldt; R Ebert
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

4.  Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain.

Authors:  Randi Ugleholdt; Jens Pedersen; Maria Rosaria Bassi; Ernst-Martin Füchtbauer; Signe Marie Jørgensen; Hanne-Louise Kissow; Nikolaj Nytofte; Steen Seier Poulsen; Mette Marie Rosenkilde; Yutaka Seino; Peter Thams; Peter Johannes Holst; Jens Juul Holst
Journal:  J Biol Chem       Date:  2011-10-25       Impact factor: 5.157

Review 5.  Regulation of lipolysis in adipocytes.

Authors:  Robin E Duncan; Maryam Ahmadian; Kathy Jaworski; Eszter Sarkadi-Nagy; Hei Sook Sul
Journal:  Annu Rev Nutr       Date:  2007       Impact factor: 11.848

6.  Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat and cafeteria diets.

Authors:  V A Gault; P L McClean; R S Cassidy; N Irwin; P R Flatt
Journal:  Diabetologia       Date:  2007-06-09       Impact factor: 10.122

7.  Race affects insulin and GLP-1 secretion and response to a long-acting somatostatin analogue in obese adults.

Authors:  P A Velasquez-Mieyer; G E Umpierrez; R H Lustig; A K Cashion; P A Cowan; M Christensen; K A Spencer; G A Burghen
Journal:  Int J Obes Relat Metab Disord       Date:  2004-02

8.  Postprandial release of gastric inhibitory polypeptide (GIP) and pancreatic polypeptide in dogs with pancreatic acinar atrophy. Correction of blunted GIP response by addition of pancreatic enzymes to a meal.

Authors:  W A Rogers; T M O'Dorisio; S E Johnson; S Cataland; R P Stradley; R G Sherding
Journal:  Dig Dis Sci       Date:  1983-04       Impact factor: 3.199

Review 9.  A compendium of G-protein-coupled receptors and cyclic nucleotide regulation of adipose tissue metabolism and energy expenditure.

Authors:  Ryan P Ceddia; Sheila Collins
Journal:  Clin Sci (Lond)       Date:  2020-03-13       Impact factor: 6.876
  9 in total

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