Literature DB >> 18547808

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.

S Bogen1, A Arasappan, W Pan, S Ruan, A Padilla, A K Saksena, V Girijavallabhan, F G Njoroge.   

Abstract

Substitutions on the P(1) cyclobutyl side chain of SCH 503034 were studied by introduction of hydroxyl and fluoro substituents. Additionally, effects of fluoro substitution on other P1 moieties were evaluated.

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Year:  2008        PMID： 18547808     DOI： 10.1016/j.bmcl.2008.05.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.

Authors:  Keith P Romano; Akbar Ali; William E Royer; Celia A Schiffer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-17       Impact factor: 11.205

2.  Azetidines and spiro azetidines as novel P2 units in hepatitis C virus NS3 protease inhibitors.

Authors:  Lavanya Bondada; Ramu Rondla; Ugo Pradere; Peng Liu; Chengwei Li; Drew Bobeck; Tamara McBrayer; Philip Tharnish; Jerome Courcambeck; Philippe Halfon; Tony Whitaker; Franck Amblard; Steven J Coats; Raymond F Schinazi
Journal:  Bioorg Med Chem Lett       Date:  2013-09-30       Impact factor: 2.823
  2 in total

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