SETTING: A 750-bed tertiary referral hospital in Central Greece. OBJECTIVE: To determine the incidence of non-tuberculous mycobacteria (NTM) respiratory infection based on the isolation of NTM in respiratory specimens, to study their clinical significance and to evaluate the differences in clinical, radiological and demographic characteristics between patients with lung disease caused by NTM and that caused by Mycobacterium tuberculosis complex (MTC). DESIGN: A 3-year period prospective study to identify patients with positive NTM and MTC respiratory specimens. RESULTS: Between January 2004 and December 2006, 564 positive NTM cultures from 214 patients and 118 MTC cultures from the same number of patients were collected. The incidence rate of clinically significant NTM lung infection was 0.67, 0.54 and 0.94 cases per 100,000 population, and that of MTC infection of the lung was respectively 5.70, 5.28 and 5.10 cases/100,000 in the three study years. Smoking habits and chronic obstructive pulmonary disease were significant risk factors for NTM disease (P < 0.05 and P < 0.001, respectively). CONCLUSIONS: NTM incidence rates were lower than those reported in the rest of Europe and the USA. Further studies are needed to determine the prevalence and the significant geographic variability of NTM and their clinical significance at the national level.
SETTING: A 750-bed tertiary referral hospital in Central Greece. OBJECTIVE: To determine the incidence of non-tuberculous mycobacteria (NTM) respiratory infection based on the isolation of NTM in respiratory specimens, to study their clinical significance and to evaluate the differences in clinical, radiological and demographic characteristics between patients with lung disease caused by NTM and that caused by Mycobacterium tuberculosis complex (MTC). DESIGN: A 3-year period prospective study to identify patients with positive NTM and MTC respiratory specimens. RESULTS: Between January 2004 and December 2006, 564 positive NTM cultures from 214 patients and 118 MTC cultures from the same number of patients were collected. The incidence rate of clinically significant NTM lung infection was 0.67, 0.54 and 0.94 cases per 100,000 population, and that of MTC infection of the lung was respectively 5.70, 5.28 and 5.10 cases/100,000 in the three study years. Smoking habits and chronic obstructive pulmonary disease were significant risk factors for NTM disease (P < 0.05 and P < 0.001, respectively). CONCLUSIONS: NTM incidence rates were lower than those reported in the rest of Europe and the USA. Further studies are needed to determine the prevalence and the significant geographic variability of NTM and their clinical significance at the national level.
Authors: Mamoudou Maiga; Sophia Siddiqui; Souleymane Diallo; Bassirou Diarra; Brehima Traoré; Yvonne R Shea; Adrian M Zelazny; Bindongo P P Dembele; Drissa Goita; Hamadoun Kassambara; Abdulrahman S Hammond; Michael A Polis; Anatole Tounkara Journal: PLoS One Date: 2012-05-16 Impact factor: 3.240
Authors: Marios Panagiotou; Andriana I Papaioannou; Konstantinos Kostikas; Maria Paraskeua; Ekaterini Velentza; Maria Kanellopoulou; Vasiliki Filaditaki; Napoleon Karagiannidis Journal: Pulm Med Date: 2014-06-10
Authors: Stefano Aliberti; Luigi Ruffo Codecasa; Andrea Gori; Giovanni Sotgiu; Maura Spotti; Antonio Di Biagio; Andrea Calcagno; Stefano Nardini; Baroukh Maurice Assael; Enrico Tortoli; Giorgio Besozzi; Maurizio Ferrarese; Alberto Matteelli; Enrico Girardi; Saverio De Lorenzo; Manuela Seia; Andrea Gramegna; Bruno Del Prato; Leonardo Terranova; Martina Oriano; Nicola Sverzellati; Mehdi Mirsaeidi; James D Chalmers; Charles S Haworth; Michael R Loebinger; Timothy Aksamit; Kevin Winthrop; Felix C Ringshausen; Giuliana Previdi; Francesco Blasi Journal: Multidiscip Respir Med Date: 2018-08-09
Authors: B Kone; Y S Sarro; M Maiga; M Sanogo; A M Somboro; B Diarra; A C G Togo; N Coulibaly; B P P Dembele; D Goita; B Baya; A Kone; S Diabaté; M A Polis; M Belson; S Dao; S Orsega; C J Achenbach; R L Murphy; S Diallo; S Siddiqui Journal: Epidemiol Infect Date: 2018-01-15 Impact factor: 4.434