Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Protein structure modeling with MODELLER.

Literature DB >> 18542861

Protein structure modeling with MODELLER.

Narayanan Eswar¹, David Eramian, Ben Webb, Min-Yi Shen, Andrej Sali.

Abstract

Genome sequencing projects have resulted in a rapid increase in the number of known protein sequences. In contrast, only about one-hundredth of these sequences have been characterized using experimental structure determination methods. Computational protein structure modeling techniques have the potential to bridge this sequence-structure gap. This chapter presents an example that illustrates the use of MODELLER to construct a comparative model for a protein with unknown structure. Automation of similar protocols (correction of protcols) has resulted in models of useful accuracy for domains in more than half of all known protein sequences.

Mesh：

Substances：
Proteins

Year: 2008 PMID： 18542861 DOI： 10.1007/978-1-60327-058-8_8

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

Keyword Cloud
Cited

421 in total

1. Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

Authors: Vladislav S Golubkov; Alexander E Aleshin; Alex Y Strongin
Journal: J Biol Chem Date: 2011-04-25 Impact factor: 5.157

2. Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.

Authors: Lihua Dong; Junyou Shi; Yongjun Liu
Journal: J Mol Model Date: 2012-03-11 Impact factor: 1.810

3. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity.

Authors: Christopher C Stobart; Alice S Lee; Xiaotao Lu; Mark R Denison
Journal: J Virol Date: 2012-02-15 Impact factor: 5.103

4. Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

Authors: Taekyung Kim; Geoffrey E Ravilious; David Sept; John A Cooper
Journal: J Biol Chem Date: 2012-03-12 Impact factor: 5.157

5. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.

Authors: Min Liu; Stephanie Kang; Soumya Ray; Justin Jackson; Alexandra D Zaitsev; Scott A Gerber; Gregory D Cuny; Marcie A Glicksman
Journal: Biochemistry Date: 2011-10-07 Impact factor: 3.162

Protein structure modeling with MODELLER.

1. Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.

2. Theoretical studies on the interaction of biphenyl inhibitors with Mycobacterium tuberculosis protein tyrosine phosphatase MptpB.

3. Temperature-sensitive mutants and revertants in the coronavirus nonstructural protein 5 protease (3CLpro) define residues involved in long-distance communication and regulation of protease activity.

4. Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein.

5. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.

6. Loops govern SH2 domain specificity by controlling access to binding pockets.

7. The annotation of full zinc proteomes.

8. Integrative structure modeling of macromolecular assemblies from proteomics data.

9. Sub-AQUA: real-value quality assessment of protein structure models.

10. Functional characterization of a cancer causing mutation in human replication protein A.