PURPOSE OF REVIEW: Oxidative stress seems to play a pathogenic role in the vicious circle linking obesity, insulin resistance and type 2 diabetes. Hypothetically, dietary antioxidants should decrease oxidative stress and therefore improve glucose metabolism. However, many interventional trials evaluating the effect of antioxidant supplementation on insulin resistance, plasma glucose levels and risk of type 2 diabetes gave inconsistent results. RECENT FINDINGS: Many studies have recently demonstrated a positive effect of vitamin supplementation and of food enriched in antioxidant (seafood, whole nut, etc.) on markers of oxidative stress, insulin resistance, fasting plasma glucose and incidence of diabetes. The present paper critically reviews the consolidated notions on dietary antioxidant in view of the recent evidences. SUMMARY: Although a definitive estimation of the impact of dietary antioxidants on glucose metabolism is still lacking, food with high antioxidant concentrations seems to have a protective effect, improving oxidative stress-mediated detrimental effects on the vicious circle among obesity, insulin resistance and redox imbalance.
PURPOSE OF REVIEW: Oxidative stress seems to play a pathogenic role in the vicious circle linking obesity, insulin resistance and type 2 diabetes. Hypothetically, dietary antioxidants should decrease oxidative stress and therefore improve glucose metabolism. However, many interventional trials evaluating the effect of antioxidant supplementation on insulin resistance, plasma glucose levels and risk of type 2 diabetes gave inconsistent results. RECENT FINDINGS: Many studies have recently demonstrated a positive effect of vitamin supplementation and of food enriched in antioxidant (seafood, whole nut, etc.) on markers of oxidative stress, insulin resistance, fasting plasma glucose and incidence of diabetes. The present paper critically reviews the consolidated notions on dietary antioxidant in view of the recent evidences. SUMMARY: Although a definitive estimation of the impact of dietary antioxidants on glucose metabolism is still lacking, food with high antioxidant concentrations seems to have a protective effect, improving oxidative stress-mediated detrimental effects on the vicious circle among obesity, insulin resistance and redox imbalance.
Authors: Ahmad A Al Ghamdi; Gamal Badr; Wael N Hozzein; Ahmed Allam; Noori S Al-Waili; Mohammed A Al-Wadaan; Olivier Garraud Journal: BMC Immunol Date: 2015-09-15 Impact factor: 3.615
Authors: Jee Wook Kim; Min Soo Byun; Dahyun Yi; Jun Ho Lee; So Yeon Jeon; Kang Ko; Gijung Jung; Han Na Lee; Jun-Young Lee; Chul-Ho Sohn; Yun-Sang Lee; Seong A Shin; Yu Kyeong Kim; Dong Young Lee Journal: Front Aging Neurosci Date: 2020-06-05 Impact factor: 5.750
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Authors: Seung-Hyun Ro; Myeongjin Nam; Insook Jang; Hwan-Woo Park; Haeli Park; Ian A Semple; Myungjin Kim; Jeong Sig Kim; Haewon Park; Paz Einat; Golda Damari; Maya Golikov; Elena Feinstein; Jun Hee Lee Journal: Proc Natl Acad Sci U S A Date: 2014-05-13 Impact factor: 11.205