BACKGROUND: The relation between the change in body mass index (BMI) through childhood and body composition in adult life is important because body composition is known to affect adult health. OBJECTIVE: The objective was to examine how the change in BMI throughout childhood is related to adult lean and fat mass. DESIGN: We examined how the change in BMI in childhood was related to adult body composition in 885 men and 1032 women born during 1934-1944, whose weights and heights during childhood were recorded serially. Adult lean and fat mass were measured by bioelectrical impedance with an 8-polar tactile electrode system. RESULTS: In these 56-70-y-old men and women, adult lean body mass index (lean mass/height(2); in kg/m(2)) was positively associated with BMI at birth (0.24 and 0.20 higher for each 1-SD increase in BMI at birth, respectively) and with more rapid gain in BMI from birth to 1 y (0.17 and 0.22), 1-2 y (0.21 and 0.20), 2-7 y (0.44 and 0.46), and 7-11 y (0.32 and 0.26) of age. Fat mass index (fat mass/height(2)) was positively associated with more rapid increases in BMI between 2 and 11 y of age. CONCLUSIONS: Rapid gain in BMI before the age of 2 y increased adult lean body mass without excess fat accumulation, whereas rapid gain in BMI in later childhood, despite the concurrent rise in lean mass, resulted in relatively larger increases in fat mass.
BACKGROUND: The relation between the change in body mass index (BMI) through childhood and body composition in adult life is important because body composition is known to affect adult health. OBJECTIVE: The objective was to examine how the change in BMI throughout childhood is related to adult lean and fat mass. DESIGN: We examined how the change in BMI in childhood was related to adult body composition in 885 men and 1032 women born during 1934-1944, whose weights and heights during childhood were recorded serially. Adult lean and fat mass were measured by bioelectrical impedance with an 8-polar tactile electrode system. RESULTS: In these 56-70-y-old men and women, adult lean body mass index (lean mass/height(2); in kg/m(2)) was positively associated with BMI at birth (0.24 and 0.20 higher for each 1-SD increase in BMI at birth, respectively) and with more rapid gain in BMI from birth to 1 y (0.17 and 0.22), 1-2 y (0.21 and 0.20), 2-7 y (0.44 and 0.46), and 7-11 y (0.32 and 0.26) of age. Fat mass index (fat mass/height(2)) was positively associated with more rapid increases in BMI between 2 and 11 y of age. CONCLUSIONS: Rapid gain in BMI before the age of 2 y increased adult lean body mass without excess fat accumulation, whereas rapid gain in BMI in later childhood, despite the concurrent rise in lean mass, resulted in relatively larger increases in fat mass.
Authors: Elisabeth Widén; Samuli Ripatti; Diana L Cousminer; Ida Surakka; Tuuli Lappalainen; Marjo-Riitta Järvelin; Johan G Eriksson; Olli Raitakari; Veikko Salomaa; Ulla Sovio; Anna-Liisa Hartikainen; Anneli Pouta; Mark I McCarthy; Clive Osmond; Eero Kajantie; Terho Lehtimäki; Jorma Viikari; Mika Kähönen; Chris Tyler-Smith; Nelson Freimer; Joel N Hirschhorn; Leena Peltonen; Aarno Palotie Journal: Am J Hum Genet Date: 2010-04-15 Impact factor: 11.025
Authors: Jeremy D Goldhaber-Fiebert; Rachel E Rubinfeld; Jay Bhattacharya; Thomas N Robinson; Paul H Wise Journal: Med Decis Making Date: 2012-05-29 Impact factor: 2.583
Authors: Xiaochuan Chen; Anna L Fahy; Alice S Green; Miranda J Anderson; Robert P Rhoads; Sean W Limesand Journal: J Physiol Date: 2010-07-19 Impact factor: 5.182
Authors: Jingmei Li; Keith Humphreys; Louise Eriksson; Kamila Czene; Jianjun Liu; Per Hall Journal: Breast Cancer Res Date: 2010-04-15 Impact factor: 6.466
Authors: C G Owen; P H Whincup; L Orfei; Q-A Chou; A R Rudnicka; A K Wathern; S J Kaye; J G Eriksson; C Osmond; D G Cook Journal: Int J Obes (Lond) Date: 2009-06-09 Impact factor: 5.095