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Literature DB >> 1854156

Effect of staggered dose of calcium on the bioavailability of ciprofloxacin.

Abstract

The effect on ciprofloxacin's bioavailability (F) of calcium carbonate given 2 h before ciprofloxacin administration in 12 male volunteers was studied. The relative F with calcium was 0.98, maximum concentration of drug in serum increased significantly from 1.98 to 2.42 mg/liter (P = 0.039), and time to maximum concentration of drug in serum decreased from 1.82 to 1.26 h (P = 0.038). Thus, a single calcium carbonate dose, administered 2 h before ciprofloxacin, does not alter the F of this quinolone.

Entities: Chemical

Mesh：

Substances：

Year: 1991 PMID： 1854156 PMCID： PMC245147 DOI： 10.1128/AAC.35.5.1004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

1. The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin.

Authors: D E Nix; W A Watson; L Handy; R W Frost; D L Rescott; H R Goldstein
Journal: Pharmacotherapy Date: 1989 Impact factor: 4.705

2. Reduced enteral absorption of ciprofloxacin in the presence of antacids.

Authors: G Höffken; K Borner; P D Glatzel; P Koeppe; H Lode
Journal: Eur J Clin Microbiol Date: 1985-06 Impact factor: 3.267

3. Antacids and ciprofloxacin pharmacokinetics.

Authors: W Bianchi; F Maggiolo; A Imbasciati; H K Ohnmeiss
Journal: Antimicrob Agents Chemother Date: 1988-06 Impact factor: 5.191

4. Effect of dose size on bioavailability of ciprofloxacin.

Authors: K I Plaisance; G L Drusano; A Forrest; C I Bustamante; H C Standiford
Journal: Antimicrob Agents Chemother Date: 1987-06 Impact factor: 5.191

5. Ciprofloxacin and antacids.

Authors: L W Fleming; T A Moreland; W K Stewart; A C Scott
Journal: Lancet Date: 1986-08-02 Impact factor: 79.321

6. Pharmacokinetics and tissue penetration of ciprofloxacin.

Authors: B Crump; R Wise; J Dent
Journal: Antimicrob Agents Chemother Date: 1983-11 Impact factor: 5.191

7. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers.

Authors: R E Polk; D P Healy; J Sahai; L Drwal; E Racht
Journal: Antimicrob Agents Chemother Date: 1989-11 Impact factor: 5.191

Review 8. Drug interactions of ciprofloxacin with other non-antibiotic agents.

Authors: E Rubinstein; S Segev
Journal: Am J Med Date: 1987-04-27 Impact factor: 4.965

Review 9. Ciprofloxacin.

Authors: D K Terp; M J Rybak
Journal: Drug Intell Clin Pharm Date: 1987 Jul-Aug

10. Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine.

Authors: B Joos; B Ledergerber; M Flepp; J D Bettex; R Lüthy; W Siegenthaler
Journal: Antimicrob Agents Chemother Date: 1985-03 Impact factor: 5.191

10 in total

10. In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.

Authors: Baishakhi Dey; Prakash Katakam; Fathi H Assaleh; Babu Rao Chandu; Shanta Kumari Adiki; Analava Mitra
Journal: J Pharm Anal Date: 2015-03-10

10 in total

Effect of staggered dose of calcium on the bioavailability of ciprofloxacin.

1. The effect of sucralfate pretreatment on the pharmacokinetics of ciprofloxacin.

2. Reduced enteral absorption of ciprofloxacin in the presence of antacids.

3. Antacids and ciprofloxacin pharmacokinetics.

4. Effect of dose size on bioavailability of ciprofloxacin.

5. Ciprofloxacin and antacids.

6. Pharmacokinetics and tissue penetration of ciprofloxacin.

7. Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers.

Review 8. Drug interactions of ciprofloxacin with other non-antibiotic agents.

Review 9. Ciprofloxacin.

10. Comparison of high-pressure liquid chromatography and bioassay for determination of ciprofloxacin in serum and urine.

1. The influence of chronic administration of calcium carbonate on the bioavailability of oral ciprofloxacin.

2. Effect of enteral feeding with ensure on oral bioavailabilities of ofloxacin and ciprofloxacin.

3. The effect of staggered dosing of sucralfate on oral bioavailability of sparfloxacin.

Review 4. Fluoroquinolones: interaction profile during enteral absorption.

Review 5. Drug interactions with quinolone antibacterials.

Review 6. Absorption interactions with fluoroquinolones. 1995 update.

Review 7. Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy.

Review 8. Pharmacokinetic drug interactions with antimicrobial agents.

Review 9. Ciprofloxacin. An updated review of its pharmacology, therapeutic efficacy and tolerability.

10. In vitro-in vivo studies of the quantitative effect of calcium, multivitamins and milk on single dose ciprofloxacin bioavailability.