Literature DB >> 18541431

Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis.

Justin B Morgenthaler1, Steven J Peters, David L Cedeño, Manuel H Constantino, Kevin A Edwards, Erin M Kamowski, Jennifer C Passini, Brian E Butkus, Alexandra M Young, Timothy D Lash, Marjorie A Jones.   

Abstract

Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro. The concentration dependency of the inhibitory effect was tested using the MTT assay. The presence of reactive oxygen species, such as singlet oxygen and superoxide, was detected using electron paramagnetic resonance spectroscopy with selected spin traps and confocal microscopy in cultures exposed to these carbaporphyrin ketals. These unique porphyrinoids show promise as potent inhibitors of Leishmania.

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Year:  2008        PMID： 18541431     DOI： 10.1016/j.bmc.2008.05.037

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  In vitro and in vivo studies of the utility of dimethyl and diethyl carbaporphyrin ketals in treatment of cutaneous leishmaniasis.

Authors:  Viviana M Taylor; David L Cedeño; Diana L Muñoz; Marjorie A Jones; Timothy D Lash; Alexandra M Young; Manuel H Constantino; Nicholas Esposito; Iván D Vélez; Sara M Robledo
Journal:  Antimicrob Agents Chemother       Date:  2011-07-25       Impact factor: 5.191

2.  Photophysical characterization and in vitro anti-leishmanial effect of 5,10,15,20-tetrakis(4-fluorophenyl) porphyrin and the metal (Zn(II), Sn(IV), Mn(III) and V(IV)) derivatives.

Authors:  Fabián Espitia-Almeida; Carlos Díaz-Uribe; William Vallejo; Doris Gómez-Camargo; Arnold R Romero Bohórquez; Ximena Zarate; Eduardo Schott
Journal:  Biometals       Date:  2022-01-07       Impact factor: 2.949

3.  Evidence That Speciation of Oxovanadium Complexes Does Not Solely Account for Inhibition of Leishmania Acid Phosphatases.

Authors:  Benjamin M Dorsey; Craig C McLauchlan; Marjorie A Jones
Journal:  Front Chem       Date:  2018-04-12       Impact factor: 5.221

Review 4.  Blue Light Disinfection in Hospital Infection Control: Advantages, Drawbacks, and Pitfalls.

Authors:  João Cabral; Rodrigues Ag
Journal:  Antibiotics (Basel)       Date:  2019-05-07

Review 5.  Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents.

Authors:  Daiana K Deda; Bernardo A Iglesias; Eduardo Alves; Koiti Araki; Celia R S Garcia
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

6.  Synthesis of Polycyclic Ether-Benzopyrans and In Vitro Inhibitory Activity against Leishmania tarentolae.

Authors:  Sarita Singh; Jacob P Grabowski; Shilpa Pohani; C Fiore Apuzzo; David C Platt; Marjorie A Jones; T Andrew Mitchell
Journal:  Molecules       Date:  2020-11-21       Impact factor: 4.411

7.  Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae.

Authors:  Amy T Christensen; Craig C McLauchlan; Anne Dolbecq; Pierre Mialane; Marjorie A Jones
Journal:  Oxid Med Cell Longev       Date:  2016-02-29       Impact factor: 6.543

8.  Sulfonamides as Inhibitors of Leishmania - Potential New Treatments for Leishmaniasis.

Authors:  Jade Katinas; Rachel Epplin; Christopher Hamaker; Marjorie A Jones
Journal:  Antiinfect Agents       Date:  2017-04
  8 in total

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