Literature DB >> 18541364

The Fbxw7/hCdc4 tumor suppressor in human cancer.

YingMeei Tan1, Olle Sangfelt, Charles Spruck.   

Abstract

Fbxw7/hCdc4 is a member of the F-box family of proteins, which function as interchangeable substrate recognition components of the SCF ubiquitin ligases. SCF(Fbxw7/hCdc4) targets several important oncoproteins including c-Myc, c-Jun, cyclin E1, and Notch, for ubiquitin-dependent proteolysis. Recent studies have shown that FBXW7/hCDC4 is mutated in a variety of human tumor types, suggesting that it is a general tumor suppressor in human cancer. Alteration of Fbxw7/hCdc4 function is linked to defects in differentiation, cellular proliferation, and genetic instability. In this review, we summarize what is known about Fbxw7/hCdc4-mediated degradation in the regulation of cellular proliferation and discuss how alteration of its function contributes to human tumorigenesis.

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Year:  2008        PMID： 18541364     DOI： 10.1016/j.canlet.2008.04.036

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  50 in total

1.  The NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.

Authors:  Valeria Tosello; Adolfo A Ferrando
Journal:  Ther Adv Hematol       Date:  2013-06

2.  The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator.

Authors:  Michael A Davis; Elizabeth A Larimore; Brian M Fissel; Jherek Swanger; Dylan J Taatjes; Bruce E Clurman
Journal:  Genes Dev       Date:  2013-01-15       Impact factor: 11.361

3.  PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer.

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Review 4.  The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation.

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Journal:  Oncogene       Date:  2010-06-14       Impact factor: 9.867

5.  MiR-182 promotes proliferation and invasion and elevates the HIF-1α-VEGF-A axis in breast cancer cells by targeting FBXW7.

Authors:  Chi-Hsiang Chiang; Pei-Yi Chu; Ming-Feng Hou; Wen-Chun Hung
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6.  Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1.

Authors:  Susanna Ekholm-Reed; Matthew S Goldberg; Michael G Schlossmacher; Steven I Reed
Journal:  Mol Cell Biol       Date:  2013-07-15       Impact factor: 4.272

7.  Uterine superficial serous carcinomas and extensive serous endometrial intraepithelial carcinomas: clinicopathological analysis of 6 patients.

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Review 8.  Gene dysregulations driven by somatic copy number aberrations-biological and clinical implications in colon tumors: a paper from the 2009 William Beaumont Hospital Symposium on Molecular Pathology.

Authors:  Manny D Bacolod; Francis Barany
Journal:  J Mol Diagn       Date:  2010-08-13       Impact factor: 5.568

9.  FBXW12, a novel F box protein-encoding gene, is deleted or methylated in some cases of epithelial ovarian cancer.

Authors:  Elsa De La Chesnaye; Juan Pablo Méndez; Ricardo López-Romero; María De Los Angeles Romero-Tlalolini; María Dolores Vergara; Mauricio Salcedo; Sergio R Ojeda
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

10.  Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.

Authors:  Elisabetta Kuhn; Ren-Chin Wu; Bin Guan; Gang Wu; Jinghui Zhang; Yue Wang; Lei Song; Xiguo Yuan; Lei Wei; Richard B S Roden; Kuan-Tin Kuo; Kentaro Nakayama; Blaise Clarke; Patricia Shaw; Narciso Olvera; Robert J Kurman; Douglas A Levine; Tian-Li Wang; Ie-Ming Shih
Journal:  J Natl Cancer Inst       Date:  2012-08-23       Impact factor: 13.506
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