OBJECTIVES: Hemodialysis (HD) population commonly show high plasma ferritin levels with a poor diagnostic value. The objective of this study is to elucidate the meaning of HD hyperferritinemia through the analysis of its ferritin iron content (FIC). DESIGN AND METHODS: FIC (iron atoms/ferritin molecule) was measured by atomic emission spectrometry. Ferritin and FIC values were correlated with iron storage and inflammation markers and the results of HD patients compared to those of septic and hemochromatosis patients. RESULTS: 1) In the whole HD population, high ferritin levels were associated to low FIC values; 2) the correlation of ferritin with iron indices and inflammation markers in HD patients was intermediate in between that of septic and hemochromatosis patients; 3) the FIC level of HD patients was lower than that of the other two groups. CONCLUSIONS: The high ferritin levels of HD patients are not synonymous with either inflammation or of high levels of iron storage. Their high levels and the low FIC values might be due to the presence inside the ferritin core of oligoelements other than iron.
OBJECTIVES: Hemodialysis (HD) population commonly show high plasma ferritin levels with a poor diagnostic value. The objective of this study is to elucidate the meaning of HD hyperferritinemia through the analysis of its ferritin iron content (FIC). DESIGN AND METHODS: FIC (iron atoms/ferritin molecule) was measured by atomic emission spectrometry. Ferritin and FIC values were correlated with iron storage and inflammation markers and the results of HDpatients compared to those of septic and hemochromatosispatients. RESULTS: 1) In the whole HD population, high ferritin levels were associated to low FIC values; 2) the correlation of ferritin with iron indices and inflammation markers in HDpatients was intermediate in between that of septic and hemochromatosispatients; 3) the FIC level of HDpatients was lower than that of the other two groups. CONCLUSIONS: The high ferritin levels of HDpatients are not synonymous with either inflammation or of high levels of iron storage. Their high levels and the low FIC values might be due to the presence inside the ferritin core of oligoelements other than iron.
Authors: Juan Manuel Ruvalcaba-López; Teodoro Córdova-Fraga; Guadalupe de la Rosa-Alvarez; Blanca Olivia Murillo-Ortiz; Juan Carlos Martínez-Espinosa; Rafael Guzmán-Cabrera; Jesús Bernal-Alvarado Journal: Lasers Med Sci Date: 2018-07-06 Impact factor: 3.161
Authors: Adam E Gaweda; Yelena Z Ginzburg; Yossi Chait; Michael J Germain; George R Aronoff; Eliezer Rachmilewitz Journal: Nephrol Dial Transplant Date: 2014-05-12 Impact factor: 5.992