Literature DB >> 18540162

Synthesis and anti-HIV activity of N'-nicotinoyl--3-(4'-hydroxy-3'-methylphenyl)-5-[substituted phenyl]-2-pyrazolines.

Mohamed A Ali1, Mohammad Shahar Yar, Anees A Siddiqui, Dharmarajan Sriram, Perumal Yogeeswari, Erick De Clercq.   

Abstract

A series of N'-nicotinoyl-3-(4'-hydroxy-3'-methylphenyl)-5-(substituted phenyl)-2-pyrazolines were synthesized by the reaction between isoniazid (INH) and chalcones and were tested for their in vitro anti-HIV activity. Among them, compound (c) showed a promising anti-HIV activity in vitro against used strains (IIIB, ROD), with IC50 of both IIIB 5.7 microM and ROD 7.0 microM.

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Year:  2007        PMID： 18540162

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN： 0001-6837            Impact factor:   0.330


  5 in total

1.  New 4-thiazolidinones of nicotinic acid with 2-Amino-6-methylbenzothiazole and their biological activity.

Authors:  Navin B Patel; Faiyazalam M Shaikh
Journal:  Sci Pharm       Date:  2010-10-24

2.  3-(4-Bromo-phen-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde.

Authors:  R Prasath; P Bhavana; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-17

3.  3-(4-Meth-oxy-phen-yl)-1-phenyl-1H-pyrazole-4-carbaldehyde.

Authors:  R Prasath; P Bhavana; Seik Weng Ng; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-12

4.  Synthesis and antimicrobial activity of new 4-thiazolidinone derivatives containing 2-amino-6-methoxybenzothiazole.

Authors:  Navin B Patel; Faiyazalam M Shaikh
Journal:  Saudi Pharm J       Date:  2010-06-02       Impact factor: 4.330

5.  Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents.

Authors:  Hamada Mohamed Ibrahim; Haider Behbehani; Mohamed H Elnagdi
Journal:  Chem Cent J       Date:  2013-07-17       Impact factor: 4.215
  5 in total

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