BACKGROUND: Paternal exposure to mutagenic agents has been suggested to affect pregnancy outcome adversely. METHODS: A nationwide data base of medically diagnosed spontaneous abortions and other pregnancies and national census data was used to evaluate the effects of men's occupational exposures on risk of spontaneous abortion in 99,186 pregnancies in Finland. Census data from the years 1975 and 1980 provided information about the occupation, industry, and socioeconomic status. A job-exposure classification was developed to classify women and their husbands according to possible occupational exposures on the basis of their occupational title and industry. RESULTS: In 10% of the pregnancies, the husband was exposed to one or more of the mutagens, and the rate of spontaneous abortion was unaffected (OR = 1.0). Of the 25 specific mutagenic exposures evaluated, paternal exposure to four (ethylene oxide, rubber chemicals, solvents used in refineries, and solvents used in the manufacturing of rubber products) was associated with an increased relative risk of spontaneous abortion. In addition, the risk of spontaneous abortion was higher among wives of rubber products workers than among unexposed men. CONCLUSIONS: Although there is some biological rationale for the findings of this study, these findings need to be confirmed by studies in which individual exposures can be measured directly.
BACKGROUND: Paternal exposure to mutagenic agents has been suggested to affect pregnancy outcome adversely. METHODS: A nationwide data base of medically diagnosed spontaneous abortions and other pregnancies and national census data was used to evaluate the effects of men's occupational exposures on risk of spontaneous abortion in 99,186 pregnancies in Finland. Census data from the years 1975 and 1980 provided information about the occupation, industry, and socioeconomic status. A job-exposure classification was developed to classify women and their husbands according to possible occupational exposures on the basis of their occupational title and industry. RESULTS: In 10% of the pregnancies, the husband was exposed to one or more of the mutagens, and the rate of spontaneous abortion was unaffected (OR = 1.0). Of the 25 specific mutagenic exposures evaluated, paternal exposure to four (ethylene oxide, rubber chemicals, solvents used in refineries, and solvents used in the manufacturing of rubber products) was associated with an increased relative risk of spontaneous abortion. In addition, the risk of spontaneous abortion was higher among wives of rubber products workers than among unexposed men. CONCLUSIONS: Although there is some biological rationale for the findings of this study, these findings need to be confirmed by studies in which individual exposures can be measured directly.
Authors: Angela R Stermer; David Klein; Shelby K Wilson; Chimeddulam Dalaijamts; Cathy Yue Bai; Susan J Hall; Samantha Madnick; Enrica Bianchi; Weihsueh A Chiu; Kim Boekelheide Journal: Environ Toxicol Pharmacol Date: 2019-02-16 Impact factor: 4.860
Authors: Caihong Xing; Francesco Marchetti; Guilan Li; Rosana H Weldon; Elaine Kurtovich; Suzanne Young; Thomas E Schmid; Luoping Zhang; Stephen Rappaport; Suramya Waidyanatha; Andrew J Wyrobek; Brenda Eskenazi Journal: Environ Health Perspect Date: 2010-01-06 Impact factor: 9.031
Authors: Mohammad Hossein Vaziri; Mohammad Ali Sadighi Gilani; Amir Kavousi; Marjan Firoozeh; Reza Khani Jazani; Ahmad Vosough Taqi Dizaj; Habibesadat Mohseni; Narges Bagery Lankarani; Mohammad Azizi; Reza Salman Yazdi Journal: Int J Fertil Steril Date: 2011-09-23