Literature DB >> 18539445

Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight.

Yun-ru Peng1, You-bin Li, Xiao-dong Liu, Jian-feng Zhang, Jin-ao Duan.   

Abstract

The antitumor activities of six C-21 steroidal glycosides isolated from the root tuber of Cynanchum auriculatum Royle ex Wight were performed according to a microculture tetrazolium (MTT) method on human tumor cell lines SMMC-7721, MCF-7 and Hela. Of these compounds, caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin were found to be of the highest effects against human tumor cell line SMMC-7721 with IC(50) values of 13.49 and 24.95 μM, respectively. Then the in vivo assay further showed that caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside and caudatin significantly inhibited the growth of transplantable H(22) tumors in mice.

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Year:  2008        PMID： 18539445     DOI： 10.1016/j.phymed.2008.02.021

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


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