| Literature DB >> 18539342 |
Marco Vercellino1, Barbara Votta, Cecilia Condello, Chiara Piacentino, Alberto Romagnolo, Aristide Merola, Elisabetta Capello, Giovanni Luigi Mancardi, Roberto Mutani, Maria Teresa Giordana, Paola Cavalla.
Abstract
An immunological function has been proposed for the choroid plexus (CP). In multiple sclerosis (MS) brains, CPs show (immunohistochemistry to HLA-DR, CD3, CD20, CD68, VCAM-1, CD138) T lymphocytes in vessels and stroma, VCAM-1 expression on endothelia, intense HLA-DR immunostaining on cells in CP stroma, among CP epithelium and on epiplexus cells. CPs in control or amyotrophic lateral sclerosis brains do not show such inflammatory changes. Intense CP inflammation is observed in viral encephalitis. Changes in MS CPs suggest persisting immune activation, with intensity similar to acute encephalitis, even in MS phases in which neurodegeneration prevails. In MS, CPs could represent a site for lymphocyte entry in the CSF and for CSF antigens presentation.Entities:
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Year: 2008 PMID： 18539342 DOI： 10.1016/j.jneuroim.2008.04.035
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478