BACKGROUND: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. METHODS: Mapping and radiofrequency ablation was performed via the venous system in two pigs. RESULTS: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. CONCLUSION: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.
BACKGROUND: When pharmacotherapy for epilepsy fails, surgical options, although efficacious, are highly invasive. We explored whether ablation of the cerebral cortex can be performed utilizing the cerebral venous system. METHODS: Mapping and radiofrequency ablation was performed via the venous system in two pigs. RESULTS: Eight targeted sites were successfully accessed and four targeted sites successfully ablated via the central cerebral venous network. CONCLUSION: Electrophysiological mapping and radiofrequency ablation of the cerebral cortex can be performed via the cerebral veins.
Authors: Prakriti Gaba; Christopher V DeSimone; Benhur D Henz; Paul A Friedman; Charles J Bruce; David R Holmes; Malini Madhavan; Krithika Vasudevan; Douglas Wahnschaffe; Steven Berhow; Andrew J Danielsen; Dorothy J Ladewig; Susan B Mikell; Susan B Johnson; Scott H Suddendorf; Tomas Kara; Gregory A Worrell; Samuel J Asirvatham Journal: J Neurol Neurophysiol Date: 2016-05-25
Authors: Mark R Bower; Matt Stead; Jamie J Van Gompel; Regina S Bower; Vlastimil Sulc; Samuel J Asirvatham; Gregory A Worrell Journal: J Neurosci Methods Date: 2013-01-08 Impact factor: 2.390
Authors: Benhur D Henz; Paul A Friedman; Charles J Bruce; David R Holmes; Mark Bower; Malini Madhavan; Christopher V DeSimone; Douglas Wahnschaffe; Steven Berhow; Andrew J Danielsen; Dorothy J Ladewig; Susan B Mikell; Susan B Johnson; Scott H Suddendorf; Tomas Kara; Gregory A Worrell; Samuel J Asirvatham Journal: Epilepsy Res Date: 2014-04-27 Impact factor: 3.045
Authors: Sam E John; Nicholas L Opie; Yan T Wong; Gil S Rind; Stephen M Ronayne; Giulia Gerboni; Sebastien H Bauquier; Terence J O'Brien; Clive N May; David B Grayden; Thomas J Oxley Journal: Sci Rep Date: 2018-05-30 Impact factor: 4.379