Literature DB >> 18538736

DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.

Xia Jiang1, Jing Tan, Jingsong Li, Saul Kivimäe, Xiaojing Yang, Li Zhuang, Puay Leng Lee, Mark T W Chan, Lawrence W Stanton, Edison T Liu, Benjamin N R Cheyette, Qiang Yu.   

Abstract

Genetic and epigenetic defects in Wnt/beta-catenin signaling play important roles in colorectal cancer progression. Here we identify DACT3, a member of the DACT (Dpr/Frodo) gene family, as a negative regulator of Wnt/beta-catenin signaling that is transcriptionally repressed in colorectal cancer. Unlike other Wnt signaling inhibitors that are silenced by DNA methylation, DACT3 repression is associated with bivalent histone modifications. Remarkably, DACT3 expression can be robustly derepressed by a pharmacological combination that simultaneously targets both histone methylation and deacetylation, leading to strong inhibition of Dishevelled (Dvl)-mediated Wnt/beta-catenin signaling and massive apoptosis of colorectal cancer cells. Our study identifies DACT3 as an important regulator of Wnt/beta-catenin signaling in colorectal cancer and suggests a potential strategy for therapeutic control of Wnt/beta-catenin signaling in colorectal cancer.

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Year:  2008        PMID： 18538736      PMCID： PMC2577847          DOI： 10.1016/j.ccr.2008.04.019

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  54 in total

1.  A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer.

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Journal:  Nat Genet       Date:  2002-05-06       Impact factor: 38.330

Review 2.  The Wnt signaling pathway in development and disease.

Authors:  Catriona Y Logan; Roel Nusse
Journal:  Annu Rev Cell Dev Biol       Date:  2004       Impact factor: 13.827

3.  Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.

Authors:  Guangjin Pan; Shulan Tian; Jeff Nie; Chuhu Yang; Victor Ruotti; Hairong Wei; Gudrun A Jonsdottir; Ron Stewart; James A Thomson
Journal:  Cell Stem Cell       Date:  2007-09-13       Impact factor: 24.633

Review 4.  Lessons from hereditary colorectal cancer.

Authors:  K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1996-10-18       Impact factor: 41.582

5.  The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

Authors:  Marc van de Wetering; Elena Sancho; Cornelis Verweij; Wim de Lau; Irma Oving; Adam Hurlstone; Karin van der Horn; Eduard Batlle; Damien Coudreuse; Anna Pavlina Haramis; Menno Tjon-Pon-Fong; Petra Moerer; Maaike van den Born; Gwen Soete; Steven Pals; Martin Eilers; Rene Medema; Hans Clevers
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

6.  Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

Authors:  Natasha S Hamblet; Nardos Lijam; Pilar Ruiz-Lozano; Jianbo Wang; Yasheng Yang; Zhenge Luo; Lin Mei; Kenneth R Chien; Daniel J Sussman; Anthony Wynshaw-Boris
Journal:  Development       Date:  2002-12       Impact factor: 6.868

Review 7.  beta-Catenin signaling: therapeutic strategies in oncology.

Authors:  Han Li; Rifat Pamukcu; W Joseph Thompson
Journal:  Cancer Biol Ther       Date:  2002 Nov-Dec       Impact factor: 4.742

8.  Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.

Authors:  L K Su; K W Kinzler; B Vogelstein; A C Preisinger; A R Moser; C Luongo; K A Gould; W F Dove
Journal:  Science       Date:  1992-05-01       Impact factor: 47.728

9.  Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors.

Authors:  Lixia Zhang; Hu Zhou; Ying Su; Zhihui Sun; Haiwen Zhang; Long Zhang; Yu Zhang; Yuanheng Ning; Ye-Guang Chen; Anming Meng
Journal:  Science       Date:  2004-10-01       Impact factor: 47.728

10.  The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway.

Authors:  Ka Yin Kwong; Yiyu Zou; Chi-Ping Day; Mien-Chie Hung
Journal:  Oncogene       Date:  2002-11-28       Impact factor: 9.867
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  114 in total

1.  ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.

Authors:  Hua Li; Benjamin G Bitler; Vinod Vathipadiekal; Marie E Maradeo; Michael Slifker; Caretha L Creasy; Peter J Tummino; Paul Cairns; Michael J Birrer; Rugang Zhang
Journal:  Cancer Prev Res (Phila)       Date:  2011-12-05

2.  Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain.

Authors:  Nathan D Okerlund; Saul Kivimäe; Cheuk Ka Tong; I-Feng Peng; Erik M Ullian; Benjamin N R Cheyette
Journal:  J Neurosci       Date:  2010-03-24       Impact factor: 6.167

Review 3.  Integrative biology--a strategy for systems biomedicine.

Authors:  Edison T Liu
Journal:  Nat Rev Genet       Date:  2009-01       Impact factor: 53.242

4.  Retinoic acid negatively regulates dact3b expression in the hindbrain of zebrafish embryos.

Authors:  Amrita Mandal; Joshua Waxman
Journal:  Gene Expr Patterns       Date:  2014-10-01       Impact factor: 1.224

5.  Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signaling.

Authors:  Hua Xue; Zhicheng Xiao; Jing Zhang; Jun Wen; Yuan Wang; Zai Chang; Jing Zhao; Xiang Gao; Jie Du; Ye-Guang Chen
Journal:  J Biol Chem       Date:  2013-04-11       Impact factor: 5.157

6.  miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.

Authors:  Xiaojing Yang; Min Feng; Xia Jiang; Zhenlong Wu; Zhimei Li; Meiyee Aau; Qiang Yu
Journal:  Genes Dev       Date:  2009-10-15       Impact factor: 11.361

7.  Inferring cancer subnetwork markers using density-constrained biclustering.

Authors:  Phuong Dao; Recep Colak; Raheleh Salari; Flavia Moser; Elai Davicioni; Alexander Schönhuth; Martin Ester
Journal:  Bioinformatics       Date:  2010-09-15       Impact factor: 6.937

8.  Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak.

Authors:  Rowena Suriben; Saul Kivimäe; Daniel A C Fisher; Randall T Moon; Benjamin N R Cheyette
Journal:  Nat Genet       Date:  2009-08-23       Impact factor: 38.330

9.  Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.

Authors:  Mi Jeong Kwon; Sung-Su Kim; Yoon-La Choi; Hun Soon Jung; Curt Balch; Su-Hyeong Kim; Yong-Sang Song; Victor E Marquez; Kenneth P Nephew; Young Kee Shin
Journal:  Carcinogenesis       Date:  2010-01-06       Impact factor: 4.944

10.  Dpr Acts as a molecular switch, inhibiting Wnt signaling when unphosphorylated, but promoting Wnt signaling when phosphorylated by casein kinase Idelta/epsilon.

Authors:  Evelyn Teran; Aron D Branscomb; Joni M Seeling
Journal:  PLoS One       Date:  2009-05-15       Impact factor: 3.240
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