Literature DB >> 18537746

Computational analysis suggests beta-defensins are processed to mature peptides by signal peptidase.

Nicholas Beckloff1, Gill Diamond.   

Abstract

Antimicrobial peptides (AMPs) are generally produced as precursor peptides containing a signal sequence, a pro-region and the mature peptide. A computational analysis of beta-defensin precursors predicts cleavage solely by signal peptidase to release the mature peptide, with no pro-region. This supports the extensive transcriptional control of beta-defensin expression compared with other AMP genes.

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Year:  2008        PMID： 18537746     DOI： 10.2174/092986608784567618

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  11 in total

Review 1.  Host defense peptides in the oral cavity and the lung: similarities and differences.

Authors:  G Diamond; N Beckloff; L K Ryan
Journal:  J Dent Res       Date:  2008-10       Impact factor: 6.116

Review 2.  Beta-defensins: what are they really doing in the oral cavity?

Authors:  G Diamond; Lk Ryan
Journal:  Oral Dis       Date:  2011-02-18       Impact factor: 3.511

Review 3.  The roles of antimicrobial peptides in innate host defense.

Authors:  Gill Diamond; Nicholas Beckloff; Aaron Weinberg; Kevin O Kisich
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

4.  Primary structure and antibacterial activity of chicken bone marrow-derived beta-defensins.

Authors:  Chrystelle Derache; Valérie Labas; Vincent Aucagne; Hervé Meudal; Céline Landon; Agnès F Delmas; Thierry Magallon; Anne-Christine Lalmanach
Journal:  Antimicrob Agents Chemother       Date:  2009-09-08       Impact factor: 5.191

Review 5.  The Dichotomous Responses Driven by β-Defensins.

Authors:  Jennifer R Shelley; Donald J Davidson; Julia R Dorin
Journal:  Front Immunol       Date:  2020-06-12       Impact factor: 7.561

6.  β-Defensins Coordinate In Vivo to Inhibit Bacterial Infections of the Trachea.

Authors:  Lisa Kathleen Ryan; Jichuan Wu; Kyell Schwartz; Sunghan Yim; Gill Diamond
Journal:  Vaccines (Basel)       Date:  2018-08-28

7.  Antimicrobial peptides from Rana [Lithobates] catesbeiana: Gene structure and bioinformatic identification of novel forms from tadpoles.

Authors:  Caren C Helbing; S Austin Hammond; Shireen H Jackman; Simon Houston; René L Warren; Caroline E Cameron; Inanç Birol
Journal:  Sci Rep       Date:  2019-02-06       Impact factor: 4.379

Review 8.  Antiviral Activities of Human Host Defense Peptides.

Authors:  David C Brice; Gill Diamond
Journal:  Curr Med Chem       Date:  2020       Impact factor: 4.530

9.  Antimicrobial peptides from fish.

Authors:  Jorge A Masso-Silva; Gill Diamond
Journal:  Pharmaceuticals (Basel)       Date:  2014-03-03

Review 10.  Salivary Antimicrobial Peptides in Early Detection of Periodontitis.

Authors:  Güliz N Güncü; Dogukan Yilmaz; Eija Könönen; Ulvi K Gürsoy
Journal:  Front Cell Infect Microbiol       Date:  2015-12-24       Impact factor: 5.293
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