Claudiu T Supuran1, Anna Di Fiore, Giuseppina De Simone. 1. Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy.
Abstract
BACKGROUND: Obesity is a widespread disease in both the developed and developing world. Few pharmacological approaches for its treatment exist at this time. OBJECTIVE: This review summarises the currently approved obesity therapies and describes a possible new approach for the treatment and prophylaxis of this disease, based on the inhibition of carbonic anhydrases (CAs, EC 4.2.1.1), enzymes involved in several steps of de novo lipogenesis, both in the mitochondria and the cytosol of cells. METHODS: Topiramate and zonisamide, two antiepileptic drugs showing strong CA inhibitory properties, have been reported as an example of this approach, as clinical data have shown that these compounds induce persistent weight loss in obese patients. CONCLUSIONS: The use of topiramate and zonisamide as lead molecules for the design of CA inhibitors targeting isozymes involved in lipogenesis could represent the beginning of a very promising new approach for the treatment of obesity.
BACKGROUND:Obesity is a widespread disease in both the developed and developing world. Few pharmacological approaches for its treatment exist at this time. OBJECTIVE: This review summarises the currently approved obesity therapies and describes a possible new approach for the treatment and prophylaxis of this disease, based on the inhibition of carbonic anhydrases (CAs, EC 4.2.1.1), enzymes involved in several steps of de novo lipogenesis, both in the mitochondria and the cytosol of cells. METHODS:Topiramate and zonisamide, two antiepileptic drugs showing strong CA inhibitory properties, have been reported as an example of this approach, as clinical data have shown that these compounds induce persistent weight loss in obesepatients. CONCLUSIONS: The use of topiramate and zonisamide as lead molecules for the design of CA inhibitors targeting isozymes involved in lipogenesis could represent the beginning of a very promising new approach for the treatment of obesity.
Authors: Jason Wagner; Balendu Sankara Avvaru; Arthur H Robbins; Andrea Scozzafava; Claudiu T Supuran; Robert McKenna Journal: Bioorg Med Chem Date: 2010-06-15 Impact factor: 3.641
Authors: Francesca Mancuso; Anna Di Fiore; Laura De Luca; Andrea Angeli; Simona M Monti; Giuseppina De Simone; Claudiu T Supuran; Rosaria Gitto Journal: ACS Med Chem Lett Date: 2020-03-04 Impact factor: 4.345
Authors: Sudabeh Iraninasab; Sana Sharifian; Ahmad Homaei; Mozafar Bagherzadeh Homaee; Tanvi Sharma; Ashok Kumar Nadda; John F Kennedy; Muhammad Bilal; Hafiz M N Iqbal Journal: Bioprocess Biosyst Eng Date: 2021-11-25 Impact factor: 3.210
Authors: Jayashree Pichake; Prashant S Kharkar; Mariangela Ceruso; Claudiu T Supuran; Mrunmayee P Toraskar Journal: ACS Med Chem Lett Date: 2014-05-16 Impact factor: 4.345
Authors: Fasil Tekola-Ayele; Ayo P Doumatey; Daniel Shriner; Amy R Bentley; Guanjie Chen; Jie Zhou; Olufemi Fasanmade; Thomas Johnson; Johnnie Oli; Godfrey Okafor; Benjami A Eghan; Kofi Agyenim-Boateng; Clement Adebamowo; Albert Amoah; Joseph Acheampong; Adebowale Adeyemo; Charles N Rotimi Journal: Mol Genet Metab Date: 2015-10-23 Impact factor: 4.797