BACKGROUND: Second generation antipsychotics (SGA) induce substantial weight gain but the mechanisms responsible for this phenomenon remain speculative. OBJECTIVE: To explore eating behaviors among SGA-treated patients and compare them with nonschizophrenic healthy sedentary individuals (controls). METHODS AND PROCEDURES: Appetite sensations were recorded before and after a standardized breakfast using visual analog scales. Three hours after breakfast, a buffet-type meal was offered to participants to document spontaneous food intake and food preferences. Satiety quotients (SQs) were calculated to determine the satiation of both meals and the Three-Factor Eating Questionnaire (TFEQ) was used to document eating behaviors. Body composition and abdominal fat distribution were assessed. RESULTS: Compared with controls (n = 20), SGA-treated patients (n = 18) showed greater adiposity indices (P < or = 0.04). Patients' degree of hunger was also higher following the standardized breakfast (P = 0.03). Moreover, patients had significantly higher cognitive dietary restraint, disinhibition, and susceptibility to hunger scores than the reference group (P < or = 0.05). Disinhibition in the reference group was positively associated with hunger triggered by external cues (r = 0.48, P = 0.03) whereas internal cues seem to mainly regulate emotional susceptibility to disinhibition in patients (r = 0.56, P = 0.02). Higher strategic restraint behavior in patients was associated with decreased satiation right after the buffet-type meal (r = -0.56, P = 0.02). DISCUSSION: These exploratory findings suggest that patients under SGA seem to develop disordered eating behaviors in response to altered appetite sensations and increased susceptibility to hunger, a factor which may influence the extent of body weight gain triggered by these drugs.
BACKGROUND: Second generation antipsychotics (SGA) induce substantial weight gain but the mechanisms responsible for this phenomenon remain speculative. OBJECTIVE: To explore eating behaviors among SGA-treated patients and compare them with nonschizophrenic healthy sedentary individuals (controls). METHODS AND PROCEDURES: Appetite sensations were recorded before and after a standardized breakfast using visual analog scales. Three hours after breakfast, a buffet-type meal was offered to participants to document spontaneous food intake and food preferences. Satiety quotients (SQs) were calculated to determine the satiation of both meals and the Three-Factor Eating Questionnaire (TFEQ) was used to document eating behaviors. Body composition and abdominal fat distribution were assessed. RESULTS: Compared with controls (n = 20), SGA-treated patients (n = 18) showed greater adiposity indices (P < or = 0.04). Patients' degree of hunger was also higher following the standardized breakfast (P = 0.03). Moreover, patients had significantly higher cognitive dietary restraint, disinhibition, and susceptibility to hunger scores than the reference group (P < or = 0.05). Disinhibition in the reference group was positively associated with hunger triggered by external cues (r = 0.48, P = 0.03) whereas internal cues seem to mainly regulate emotional susceptibility to disinhibition in patients (r = 0.56, P = 0.02). Higher strategic restraint behavior in patients was associated with decreased satiation right after the buffet-type meal (r = -0.56, P = 0.02). DISCUSSION: These exploratory findings suggest that patients under SGA seem to develop disordered eating behaviors in response to altered appetite sensations and increased susceptibility to hunger, a factor which may influence the extent of body weight gain triggered by these drugs.
Authors: Kimberly R Warren; Robert W Buchanan; Stephanie Feldman; Robert R Conley; Jared Linthicum; Mary Patricia Ball; Fang Liu; Robert P McMahon; David A Gorelick; Marilyn A Huestis; Deanna L Kelly Journal: J Clin Psychopharmacol Date: 2013-02 Impact factor: 3.153
Authors: Angelique F Ralph; Leah Brennan; Sue Byrne; Belinda Caldwell; Jo Farmer; Laura M Hart; Gabriella A Heruc; Sarah Maguire; Milan K Piya; Julia Quin; Sarah K Trobe; Andrew Wallis; A J Williams-Tchen; Phillipa Hay Journal: J Eat Disord Date: 2022-08-18
Authors: Louise Benarroch; Chantel Kowalchuk; Virginia Wilson; Celine Teo; Melanie Guenette; Araba Chintoh; Yasika Nesarajah; Valerie Taylor; Peter Selby; Paul Fletcher; Gary J Remington; Margaret K Hahn Journal: Psychopharmacology (Berl) Date: 2016-06-01 Impact factor: 4.530
Authors: Johan Fernø; Luis Varela; Silje Skrede; María Jesús Vázquez; Rubén Nogueiras; Carlos Diéguez; Antonio Vidal-Puig; Vidar M Steen; Miguel López Journal: PLoS One Date: 2011-06-13 Impact factor: 3.240