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Literature DB >> 18534373

Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies.

Rachel Ruckdeschel Smith¹, Lucio Barile, Elisa Messina, Eduardo Marbán.

Abstract

New approaches for cardiac repair have been enabled by the discovery that the heart contains its own reservoir of stem cells. In Part 1 of this review, we discussed various cardiac stem cell populations, reviewed our own work on cardiosphere-derived cells from human hearts, and outlined large animal preclinical models testing the regenerative potential of cardiac stem cells. Here we continue with a discussion on other adult stem cell sources with clinical potential. We summarize the critical safety issues associated with stem cell therapy and present the possible proarrhythmic and antiarrhythmic effects of stem cell transplantation. We discuss the outcomes of clinical stem cell trials and identify the technical, ethical, and practical issues facing the clinical application of cardiac stem cells.

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Mesh：

Year: 2008 PMID： 18534373 PMCID： PMC2717007 DOI： 10.1016/j.hrthm.2008.02.011

Source DB: PubMed Journal: Heart Rhythm ISSN： 1547-5271 Impact factor: 6.343

94 in total

1. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial.

Authors: Kai C Wollert; Gerd P Meyer; Joachim Lotz; Stefanie Ringes-Lichtenberg; Peter Lippolt; Christiane Breidenbach; Stephanie Fichtner; Thomas Korte; Burkhard Hornig; Diethelm Messinger; Lubomir Arseniev; Bernd Hertenstein; Arnold Ganser; Helmut Drexler
Journal: Lancet Date: 2004 Jul 10-16 Impact factor: 79.321

2. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro.

Authors: Wenrong Xu; Xiran Zhang; Hui Qian; Wei Zhu; Xiaochun Sun; Jiabo Hu; Hong Zhou; Yongchang Chen
Journal: Exp Biol Med (Maywood) Date: 2004-07

3. Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-up.

Authors: Pieter C Smits; Robert-Jan M van Geuns; Don Poldermans; Manolis Bountioukos; Emile E M Onderwater; Chi Hang Lee; Alex P W M Maat; Patrick W Serruys
Journal: J Am Coll Cardiol Date: 2003-12-17 Impact factor: 24.094

4. Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.

Authors: Jens M Nygren; Stefan Jovinge; Martin Breitbach; Petter Säwén; Wilhelm Röll; Jürgen Hescheler; Jalal Taneera; Bernd K Fleischmann; Sten Eirik W Jacobsen
Journal: Nat Med Date: 2004-04-25 Impact factor: 53.440

5. Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant.

Authors: James M Weimann; Clas B Johansson; Angelica Trejo; Helen M Blau
Journal: Nat Cell Biol Date: 2003-10-15 Impact factor: 28.824

6. Electrophysiological properties of human mesenchymal stem cells.

Authors: Jürgen F Heubach; Eva M Graf; Judith Leutheuser; Manja Bock; Bartosz Balana; Ihor Zahanich; Torsten Christ; Sabine Boxberger; Erich Wettwer; Ursula Ravens
Journal: J Physiol Date: 2003-10-24 Impact factor: 5.182

7. Mesenchymal stem cells can be differentiated into endothelial cells in vitro.

Authors: Joachim Oswald; Sabine Boxberger; Birgitte Jørgensen; Silvia Feldmann; Gerhard Ehninger; Martin Bornhäuser; Carsten Werner
Journal: Stem Cells Date: 2004 Impact factor: 6.277

8. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy.

Authors: Emerson C Perin; Hans F R Dohmann; Radovan Borojevic; Suzana A Silva; Andre L S Sousa; Guilherme V Silva; Claudio T Mesquita; Luciano Belém; William K Vaughn; Fernando O D Rangel; Joao A R Assad; Antonio C Carvalho; Rodrigo V C Branco; Maria I D Rossi; Hans J F Dohmann; James T Willerson
Journal: Circulation Date: 2004-09-14 Impact factor: 29.690

9. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts.

Authors: Charles E Murry; Mark H Soonpaa; Hans Reinecke; Hidehiro Nakajima; Hisako O Nakajima; Michael Rubart; Kishore B S Pasumarthi; Jitka Ismail Virag; Stephen H Bartelmez; Veronica Poppa; Gillian Bradford; Joshua D Dowell; David A Williams; Loren J Field
Journal: Nature Date: 2004-03-21 Impact factor: 49.962

10. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.

Authors: Leora B Balsam; Amy J Wagers; Julie L Christensen; Theo Kofidis; Irving L Weissman; Robert C Robbins
Journal: Nature Date: 2004-03-21 Impact factor: 49.962

22 in total

Review 1. Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.

Authors: B Alexander Yi; Oliver Wernet; Kenneth R Chien
Journal: J Clin Invest Date: 2010-01 Impact factor: 14.808

2. A mechanistic roadmap for the clinical application of cardiac cell therapies.

Authors: Eduardo Marbán
Journal: Nat Biomed Eng Date: 2018-06-11 Impact factor: 25.671

3. Differentiation induction of mouse cardiac stem cells into sinus node-like cells by co-culturing with sinus node.

Authors: Yi-Bing Fang; Xuan Liu; Jing Wen; Xiao-Jun Tang; Feng-Xu Yu; Ming-Bin Deng; Chang-Xue Wu; Bin Liao
Journal: Int J Clin Exp Pathol Date: 2014-04-15

4. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice.

Authors: Isotta Chimenti; Rachel Ruckdeschel Smith; Tao-Sheng Li; Gary Gerstenblith; Elisa Messina; Alessandro Giacomello; Eduardo Marbán
Journal: Circ Res Date: 2010-01-28 Impact factor: 17.367

5. Cellular and molecular characterization of human cardiac stem cells reveals key features essential for their function and safety.

Authors: Sadaf Vahdat; Seyed Ahmad Mousavi; Gholamreza Omrani; Maziar Gholampour; Fattah Sotoodehnejadnematalahi; Zaniar Ghazizadeh; Javad Gharechahi; Hossein Baharvand; Ghasem Hosseini Salekdeh; Nasser Aghdami
Journal: Stem Cells Dev Date: 2015-06-15 Impact factor: 3.272

6. Engineered electrical conduction tract restores conduction in complete heart block: from in vitro to in vivo proof of concept.

Authors: Eugenio Cingolani; Vittoria Ionta; Ke Cheng; Alessandro Giacomello; Hee Cheol Cho; Eduardo Marbán
Journal: J Am Coll Cardiol Date: 2014-12-23 Impact factor: 24.094

7. Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy.

Authors: Peter V Johnston; Tetsuo Sasano; Kevin Mills; Robert Evers; Shuo-Tsan Lee; Rachel Ruckdeschel Smith; Albert C Lardo; Shenghan Lai; Charles Steenbergen; Gary Gerstenblith; Richard Lange; Eduardo Marbán
Journal: Circulation Date: 2009-09-08 Impact factor: 29.690

8. Comparison of cardiac stem cells and mesenchymal stem cells transplantation on the cardiac electrophysiology in rats with myocardial infarction.

Authors: Shao-Xin Zheng; Yin-Lun Weng; Chang-Qing Zhou; Zhu-Zhi Wen; Hui Huang; Wei Wu; Jing-Feng Wang; Tong Wang
Journal: Stem Cell Rev Rep Date: 2013-06 Impact factor: 5.739

9. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.

Authors: Changsung Kim; Maryam Majdi; Peng Xia; Karen A Wei; Maria Talantova; Sean Spiering; Brandon Nelson; Mark Mercola; Huei-Sheng Vincent Chen
Journal: Stem Cells Dev Date: 2010-06 Impact factor: 3.272

Review 10. Cardiac stem cells in patients with ischemic cardiomyopathy: discovery, translation, and clinical investigation.

Authors: John H Loughran; Julius B Elmore; Momina Waqar; Atul R Chugh; Roberto Bolli
Journal: Curr Atheroscler Rep Date: 2012-10 Impact factor: 5.113