Literature DB >> 18533949

Developmental dysplasia of the hip: risk markers, clinical screening and outcome.

Chen Stein-Zamir1, Irina Volovik, Shmuel Rishpon, Roger Sabi.   

Abstract

BACKGROUND: Early detection, diagnosis and treatment of developmental dysplasia/dislocation of hip (DDH) are essential in preventing further disability and quality of life impairment in children. DDH risk markers and association between the age of clinical screening and outcome, were evaluated.
METHODS: Clinical screening at ages birth, 6 and 13 weeks was performed in 8145 infants by pediatricians. Infants suspected for DDH were referred to the community hospital clinic for clinical evaluation by a pediatric orthopedic surgeon, imaging procedures and follow up. Demographic and perinatal characteristics of the children with suspected (n= 77) and diagnosed DDH (n= 51) were compared to matched controls (n= 154).
RESULTS: The rate of suspected DDH was 0.95% and that of diagnosed DDH was 0.63%. Female gender, firstborn child and breech presentation were significantly more frequent among cases versus controls (odds ratio [OR]: 4.3, 2.7, and 6 respectively; P < 0.05). The highest positive predictive value (95.5%) in physical evaluation was any evidence of a dislocatable hip. The proportion of DDH among infants referred from the newborn department was significantly higher (OR, 4.4). DDH diagnosis after 6 weeks of age was associated with a higher likelihood of subsequent surgery and motor disability. Untoward outcome was significantly associated with increasing age of referral both at ages of 6 and 13 weeks (P < 0.05).
CONCLUSIONS: Children with DDH have certain specific demographic and perinatal risk markers. Clinical screening targeted towards early diagnosis may lessen the need for surgical intervention and the risk of disability or motor handicap.

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Year:  2008        PMID: 18533949     DOI: 10.1111/j.1442-200X.2008.02575.x

Source DB:  PubMed          Journal:  Pediatr Int        ISSN: 1328-8067            Impact factor:   1.524


  25 in total

1.  Asymmetrical thigh creases or isolated thigh crease may be a false positive sign with low predictive value in the diagnosis of developmental dysplasia of the hip in infants: a prospective cohort study of 117 patients.

Authors:  Panagiotis Touzopoulos; Nikolaos G Markeas
Journal:  Eur J Orthop Surg Traumatol       Date:  2019-08-12

2.  Altered Chondrocyte Apoptosis Status in Developmental Hip Dysplasia in Rabbits.

Authors:  Yi-Shan Wei; Dai-He Li; Wan-Lin Liu; Dian-Ming Jiang
Journal:  Balkan Med J       Date:  2016-11-01       Impact factor: 2.021

3.  Routine screening for developmental dysplasia of the hip by chiropractors: a case report of late diagnosis in an infant.

Authors:  Christian J Fludder; Braden G Keil
Journal:  J Can Chiropr Assoc       Date:  2020-08

4.  Prevalence of developmental dysplasia of the hip in preterm infants with maternal risk factors.

Authors:  Cenk Sezer; Serhan Unlu; Ismail Demirkale; Murat Altay; Safa Kapicioglu; Murat Bozkurt
Journal:  J Child Orthop       Date:  2013-05-18       Impact factor: 1.548

5.  Early articular cartilage degeneration in a developmental dislocation of the hip model results from activation of β-catenin.

Authors:  Bo Ning; Jun Sun; Yi Yuan; Jie Yao; Peng Wang; Ruixue Ma
Journal:  Int J Clin Exp Pathol       Date:  2014-03-15

6.  The role of TGFβ1 stimulating ROCK I signal pathway to reorganize actin in a rat experimental model of developmental dysplasia of the hip.

Authors:  Xinhong Pei; Yueqiang Mo; Bo Ning; Zhe Yuan; Luying Peng; Ruixue Ma
Journal:  Mol Cell Biochem       Date:  2014-02-27       Impact factor: 3.396

7.  The Otto Aufranc Award: Identification of a 4 Mb region on chromosome 17q21 linked to developmental dysplasia of the hip in one 18-member, multigeneration family.

Authors:  George Feldman; Chelsea Dalsey; Kasia Fertala; David Azimi; Paolo Fortina; Marcella Devoto; Maurizio Pacifici; Javad Parvizi
Journal:  Clin Orthop Relat Res       Date:  2009-09-11       Impact factor: 4.176

8.  Developmental dysplasia of the hip - angle trends after operation in different age groups.

Authors:  Sonja Milasinovic; Radivoj Brdar; Ivana Petronic; Dejan Nikolic; Dragana Cirovic
Journal:  Arch Med Sci       Date:  2010-10-26       Impact factor: 3.318

9.  Integrative Analysis of MicroRNA and mRNA Sequencing Data Identifies Novel Candidate Genes and Pathways for Developmental Dysplasia of Hip.

Authors:  Bolun Cheng; Yumeng Jia; Yan Wen; Weikun Hou; Ke Xu; Chujun Liang; Shiqiang Cheng; Li Liu; Xiaomeng Chu; Jing Ye; Yao Yao; Feng Zhang; Peng Xu
Journal:  Cartilage       Date:  2021-02-01       Impact factor: 3.117

Review 10.  The epidemiology and demographics of hip dysplasia.

Authors:  Randall T Loder; Elaine N Skopelja
Journal:  ISRN Orthop       Date:  2011-10-10
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