| Literature DB >> 18529009 |
Jishu Naskar1, Michael G B Drew, Ishani Deb, Sumantra Das, Arindam Banerjee.
Abstract
A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides Abeta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.Entities:
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Year: 2008 PMID： 18529009 DOI： 10.1021/ol8007217
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005