| Literature DB >> 18528910 |
Daisuke Yasokawa1, Satomi Murata, Emiko Kitagawa, Yumiko Iwahashi, Ryoji Nakagawa, Tazusa Hashido, Hitoshi Iwahashi.
Abstract
The effect of the heavy metal copper on the expression of a wide spectrum of genes was analyzed by using a DNA microarray. The gene expression profile of baker's yeast Saccharomyces cerevisiae grown in a medium containing a sublethal concentration of cupric sulfate was compared with that of yeast grown in a normal medium. Among approximately 6000 yeast ORFs, 143 ORFs were induced more than twofold to resist copper toxicity after exposure to copper. Copper metallothionein CUP1-1 and CUP1-2 were induced more than 20-fold. Some genes related to sulfur metabolism and oxidative stress response were also up-regulated. This DNA microarray analysis identified several molecular targets of copper toxicity.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18528910 DOI： 10.1002/tox.20406
Source DB: PubMed Journal: Environ Toxicol ISSN： 1520-4081 Impact factor: 4.119