Literature DB >> 18525269

HIV Gag-specific immune responses predict the rate of CD4 decline.

Yoav Peretz1, Christos M Tsoukas, Nicole F Bernard.   

Abstract

In the present study, we assessed whether Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline. Although neither the breadth nor the magnitude of the proteome-wide HIV-specific IFN-gamma response correlated with viral load or rate of CD4 decline, the preferential targeting of Gag is associated with slower annual CD4 T cell decline.

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Year:  2008        PMID： 18525269     DOI： 10.1097/QAD.0b013e3283021a76

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  5 in total

1.  HLA-DQB1*06 and breadth of Nef core region-specific T-cell response are associated with slow disease progression in antiretroviral therapy-naive Chinese HIV-1 subtype B patients.

Authors:  Weihua Li; Chuanyun Li; Wei Xia; Xiuhui Li
Journal:  Hum Vaccin Immunother       Date:  2017-10-03       Impact factor: 3.452

2.  Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.

Authors:  Mareike Meythaler; Zichun Wang; Amanda Martinot; Sarah Pryputniewicz; Melissa Kasheta; Harold M McClure; Shawn P O'Neil; Amitinder Kaur
Journal:  J Immunol       Date:  2011-03-25       Impact factor: 5.422

3.  Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.

Authors:  Zabrina Brumme; Bingxia Wang; Kriebashne Nair; Chanson Brumme; Chantal de Pierres; Shabashini Reddy; Boris Julg; Eshia Moodley; Christina Thobakgale; Zhigang Lu; Mary van der Stok; Karen Bishop; Zenele Mncube; Fundisiwe Chonco; Yuko Yuki; Nicole Frahm; Christian Brander; Mary Carrington; Kenneth Freedberg; Photini Kiepiela; Philip Goulder; Bruce Walker; Thumbi Ndung'u; Elena Losina
Journal:  Clin Infect Dis       Date:  2009-09-15       Impact factor: 9.079

4.  Human leucocyte antigen-Bw4 and Gag-specific T cell responses are associated with slow disease progression in HIV-1B-infected anti-retroviral therapy-naive Chinese.

Authors:  W-H Li; C-Y Li; H-B Yang; H-P Zhang; X Zhang; L-S Kong; X-N Xu; S-C Lu; H-P Yan
Journal:  Clin Exp Immunol       Date:  2013-03       Impact factor: 4.330

5.  Host HLA B*allele-associated multi-clade Gag T-cell recognition correlates with slow HIV-1 disease progression in antiretroviral therapy-naïve Ugandans.

Authors:  Jennifer Serwanga; Leigh Anne Shafer; Edward Pimego; Betty Auma; Christine Watera; Samantha Rowland; David Yirrell; Pietro Pala; Heiner Grosskurth; Jimmy Whitworth; Frances Gotch; Pontiano Kaleebu
Journal:  PLoS One       Date:  2009-01-14       Impact factor: 3.240
  5 in total

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