OBJECTIVES: To evaluate whether hourly changes in fine particle (PM(2.5), diameter<2.5 microm) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. METHODS: 41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. The occurrence of ST segment depressions >0.1 mV was recorded during submaximal exercise tests. Hourly variations in personal PM(2.5) exposure and outdoor levels of PM(2.5) and ultrafine particles (<0.1 microm) were recorded for 24 h before a clinic visit. Associations between particulate air pollution and ST segment depressions were evaluated using logistic regression. RESULTS: Both personal and outdoor PM(2.5) concentrations, but not outdoor ultrafine particle counts, were associated with ST segment depressions. The odds ratio (per 10 microg/m(3)) for personal PM(2.5) concentration during the hour preceding a clinic visit was 3.26 (95% CI 1.07 to 9.99) and for 4 h average outdoor PM(2.5) it was 2.47 (95% CI 1.05 to 5.85). CONCLUSIONS: Even very short-term elevations in fine particle exposure might increase the risk of myocardial ischaemia. The precise mechanism is still unknown but could involve changes in autonomic nervous control of the heart.
OBJECTIVES: To evaluate whether hourly changes in fine particle (PM(2.5), diameter<2.5 microm) exposure or outdoor particle concentrations are associated with rapid ischaemic responses. METHODS: 41 non-smoking elderly people with coronary heart disease were followed up with biweekly clinic visits in Helsinki, Finland. The occurrence of ST segment depressions >0.1 mV was recorded during submaximal exercise tests. Hourly variations in personal PM(2.5) exposure and outdoor levels of PM(2.5) and ultrafine particles (<0.1 microm) were recorded for 24 h before a clinic visit. Associations between particulate air pollution and ST segment depressions were evaluated using logistic regression. RESULTS: Both personal and outdoor PM(2.5) concentrations, but not outdoor ultrafine particle counts, were associated with ST segment depressions. The odds ratio (per 10 microg/m(3)) for personal PM(2.5) concentration during the hour preceding a clinic visit was 3.26 (95% CI 1.07 to 9.99) and for 4 h average outdoor PM(2.5) it was 2.47 (95% CI 1.05 to 5.85). CONCLUSIONS: Even very short-term elevations in fine particle exposure might increase the risk of myocardial ischaemia. The precise mechanism is still unknown but could involve changes in autonomic nervous control of the heart.
Authors: Hualiang Lin; Tao Liu; Jianpeng Xiao; Weilin Zeng; Lingchuan Guo; Xing Li; Yanjun Xu; Yonghui Zhang; Jen Jen Chang; Michael G Vaughn; Zhengmin Min Qian; Wenjun Ma Journal: J Expo Sci Environ Epidemiol Date: 2016-11-02 Impact factor: 5.563
Authors: Ralph J Delfino; Norbert Staimer; Thomas Tjoa; Mohammad Arhami; Andrea Polidori; Daniel L Gillen; Michael T Kleinman; James J Schauer; Constantinos Sioutas Journal: Environ Health Perspect Date: 2010-02-02 Impact factor: 9.031
Authors: Mi-Sun Lee; Ki-Do Eum; Ema G Rodrigues; Shannon R Magari; Shona C Fang; Geoffrey A Modest; David C Christiani Journal: Am J Cardiol Date: 2015-10-17 Impact factor: 2.778
Authors: Mehdi S Hazari; Justin Callaway; Darrell W Winsett; Christina Lamb; Najwa Haykal-Coates; Q Todd Krantz; Charly King; Daniel L Costa; Aimen K Farraj Journal: Environ Health Perspect Date: 2012-04-27 Impact factor: 9.031
Authors: Ralph J Delfino; Daniel L Gillen; Thomas Tjoa; Norbert Staimer; Andrea Polidori; Mohammad Arhami; Constantinos Sioutas; John Longhurst Journal: Environ Health Perspect Date: 2010-10-21 Impact factor: 9.031