| Literature DB >> 18524586 |
Hendra Gunosewoyo1, Jun Liu Guo, Maxwell R Bennett, Mark J Coster, Michael Kassiou.
Abstract
Polycyclic amides 2 and 5-9 were successfully synthesised and their lipophilicity profiles were evaluated using reverse-phase HPLC. All synthesised compounds possessed P2X7R antagonistic properties when tested on rat spinal cord microglia cells. Extensive screening for binding to other neuroreceptor subtypes demonstrated their P2X7 selectivity.Entities:
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Year: 2008 PMID： 18524586 DOI： 10.1016/j.bmcl.2008.05.062
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823