Literature DB >> 18524581

Fungicidal activity of truncated analogues of dihydrosphingosine.

Karin Thevissen1, Ulrik Hillaert, Els M K Meert, Kuen K Chow, Bruno P A Cammue, Serge Van Calenbergh, Isabelle E J A François.   

Abstract

The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.

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Year:  2008        PMID： 18524581     DOI： 10.1016/j.bmcl.2008.05.067

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga.

Authors:  Carmit Ziv; Sergey Malitsky; Alaa Othman; Shifra Ben-Dor; Yu Wei; Shuning Zheng; Asaph Aharoni; Thorsten Hornemann; Assaf Vardi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-16       Impact factor: 11.205

2.  Sphingolipids and mitochondrial function in budding yeast.

Authors:  Pieter Spincemaille; Nabil Matmati; Yusuf A Hannun; Bruno P A Cammue; Karin Thevissen
Journal:  Biochim Biophys Acta       Date:  2014-06-25

3.  Stimulation of superoxide production increases fungicidal action of miconazole against Candida albicans biofilms.

Authors:  Kaat De Cremer; Katrijn De Brucker; Ines Staes; Annelies Peeters; Freija Van den Driessche; Tom Coenye; Bruno P A Cammue; Karin Thevissen
Journal:  Sci Rep       Date:  2016-06-07       Impact factor: 4.379

4.  Effect of the multifunctional cosmetic ingredient sphinganine on hair loss in males and females with diffuse hair reduction.

Authors:  Nicole Gerlach; Matthias Mentel; Tim Köhler; Benjamin Tuchscherer; Birgit Garbe; Jasmina Ülker; Hagen Tronnier; Ulrike Heinrich; Mike Farwick
Journal:  Clin Cosmet Investig Dermatol       Date:  2016-09-08

5.  Identification of fungicidal 2,6-disubstituted quinolines with activity against Candida biofilms.

Authors:  Nicolas Delattin; Dorothée Bardiot; Arnaud Marchand; Patrick Chaltin; Katrijn De Brucker; Bruno P A Cammue; Karin Thevissen
Journal:  Molecules       Date:  2012-10-18       Impact factor: 4.411

6.  The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens.

Authors:  René Glenz; Agnes Kaiping; Delia Göpfert; Hannah Weber; Benjamin Lambour; Marvin Sylvester; Christian Fröschel; Martin J Mueller; Mohamed Osman; Frank Waller
Journal:  Sci Rep       Date:  2022-01-20       Impact factor: 4.379
  6 in total

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