Literature DB >> 18524394

Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha.

Hikoichiro Maegawa1, Emi E Nakayama, Ayumu Kuroishi, Tatsuo Shioda.   

Abstract

Tripartite motif protein (TRIM) 5alpha is a restriction factor of human immunodeficiency virus type 1 in Old World monkey cell. It was found that both naturally occurring and artificial TRIM5alpha variants lacking the SPRY domain could silence TRIM5alpha activity. Specifically, the artificial TRIM5alpha mutant could suppress TRIM5alpha activity of various primate species with even higher efficiency than could small interfering RNAs. The findings indicate that TRIM5alpha variants lacking the SPRY domain are useful for silencing TRIM5alpha activity.

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Year:  2008        PMID： 18524394     DOI： 10.1016/j.jviromet.2008.04.012

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  9 in total

1.  Modulation of TRIM5alpha activity in human cells by alternatively spliced TRIM5 isoforms.

Authors:  Emilie Battivelli; Julie Migraine; Denise Lecossier; Saori Matsuoka; Danielle Perez-Bercoff; Sentob Saragosti; François Clavel; Allan J Hance
Journal:  J Virol       Date:  2011-06-01       Impact factor: 5.103

Review 2.  Restriction of HIV-1 and other retroviruses by TRIM5.

Authors:  Barbie K Ganser-Pornillos; Owen Pornillos
Journal:  Nat Rev Microbiol       Date:  2019-07-16       Impact factor: 60.633

3.  A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection.

Authors:  Emi E Nakayama; Toshiaki Nakajima; Gurvinder Kaur; Jun-ich Mimaya; Hiroshi Terunuma; Narinder Mehra; Akinori Kimura; Tatsuo Shioda
Journal:  AIDS Res Hum Retroviruses       Date:  2013-02-26       Impact factor: 2.205

4.  Identification of postentry restrictions to Mason-Pfizer monkey virus infection in New World monkey cells.

Authors:  William E Diehl; Elizabeth Stansell; Shari M Kaiser; Michael Emerman; Eric Hunter
Journal:  J Virol       Date:  2008-09-17       Impact factor: 5.103

5.  Tripartite Motif (TRIM) 12c, a Mouse Homolog of TRIM5, Is a Ubiquitin Ligase That Stimulates Type I IFN and NF-κB Pathways along with TNFR-Associated Factor 6.

Authors:  Tsung-Hsien Chang; Ryusuke Yoshimi; Keiko Ozato
Journal:  J Immunol       Date:  2015-10-26       Impact factor: 5.422

6.  A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5 alpha.

Authors:  Ayumu Kuroishi; Katarzyna Bozek; Tatsuo Shioda; Emi E Nakayama
Journal:  Retrovirology       Date:  2010-07-07       Impact factor: 4.602

7.  Modification of a loop sequence between alpha-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA alpha-helices 4 and 5 loop improves replication in cynomolgus monkey cells.

Authors:  Ayumu Kuroishi; Akatsuki Saito; Yasuhiro Shingai; Tatsuo Shioda; Masako Nomaguchi; Akio Adachi; Hirofumi Akari; Emi E Nakayama
Journal:  Retrovirology       Date:  2009-08-03       Impact factor: 4.602

8.  Delaying reverse transcription does not increase sensitivity of HIV-1 to human TRIM5α.

Authors:  Emilie Battivelli; Denise Lecossier; François Clavel; Allan J Hance
Journal:  PLoS One       Date:  2013-01-08       Impact factor: 3.240

9.  Macaque-tropic human immunodeficiency virus type 1: breaking out of the host restriction factors.

Authors:  Akatsuki Saito; Hirofumi Akari
Journal:  Front Microbiol       Date:  2013-07-09       Impact factor: 5.640
  9 in total

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