BACKGROUND: The transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population. METHODS: To evaluate whether TGFB1 L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers. RESULTS: We found no evidence of association between TGFB1 L10P and breast cancer risk in either BRCA1 or BRCA2 mutation carriers. The per-allele HR for the L10P variant was 1.01 (95%CI: 0.92-1.11) in BRCA1 carriers and 0.92 (95%CI: 0.81-1.04) in BRCA2 mutation carriers. CONCLUSIONS: These results do not support the hypothesis that TGFB1 L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.
BACKGROUND: The transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population. METHODS: To evaluate whether TGFB1L10P also modifies the risk of breast cancer in BRCA1 or BRCA2 mutation carriers, we undertook a multi-center study of 3,442 BRCA1 and 2,095 BRCA2 mutation carriers. RESULTS: We found no evidence of association between TGFB1L10P and breast cancer risk in either BRCA1 or BRCA2 mutation carriers. The per-allele HR for the L10P variant was 1.01 (95%CI: 0.92-1.11) in BRCA1 carriers and 0.92 (95%CI: 0.81-1.04) in BRCA2 mutation carriers. CONCLUSIONS: These results do not support the hypothesis that TGFB1L10P genotypes modify the risk of breast cancer in BRCA1 or BRCA2 mutation carriers.
Authors: A Antoniou; P D P Pharoah; S Narod; H A Risch; J E Eyfjord; J L Hopper; N Loman; H Olsson; O Johannsson; A Borg; B Pasini; P Radice; S Manoukian; D M Eccles; N Tang; E Olah; H Anton-Culver; E Warner; J Lubinski; J Gronwald; B Gorski; H Tulinius; S Thorlacius; H Eerola; H Nevanlinna; K Syrjäkoski; O-P Kallioniemi; D Thompson; C Evans; J Peto; F Lalloo; D G Evans; D F Easton Journal: Am J Hum Genet Date: 2003-04-03 Impact factor: 11.025
Authors: Sunil R Lakhani; Marc J Van De Vijver; Jocelyne Jacquemier; Thomas J Anderson; Peter P Osin; Lesley McGuffog; Douglas F Easton Journal: J Clin Oncol Date: 2002-05-01 Impact factor: 44.544
Authors: Loïc Le Marchand; Christopher A Haiman; David van den Berg; Lynne R Wilkens; Laurence N Kolonel; Brian E Henderson Journal: Cancer Epidemiol Biomarkers Prev Date: 2004-03 Impact factor: 4.254
Authors: Alison M Dunning; Peter D Ellis; Simon McBride; Heidi L Kirschenlohr; Catherine S Healey; Paul R Kemp; Robert N Luben; Jenny Chang-Claude; Arto Mannermaa; Vesa Kataja; Paul D P Pharoah; Douglas F Easton; Bruce A J Ponder; James C Metcalfe Journal: Cancer Res Date: 2003-05-15 Impact factor: 12.701
Authors: Peter Krippl; Uwe Langsenlehner; Wilfried Renner; Babak Yazdani-Biuki; Gerald Wolf; Thomas C Wascher; Bernhard Paulweber; Babak Bahadori; Hellmut Samonigg Journal: Cancer Lett Date: 2003-11-25 Impact factor: 8.679
Authors: Annegien Broeks; Marjanka K Schmidt; Mark E Sherman; Fergus J Couch; John L Hopper; Gillian S Dite; Carmel Apicella; Letitia D Smith; Fleur Hammet; Melissa C Southey; Laura J Van 't Veer; Renate de Groot; Vincent T H B M Smit; Peter A Fasching; Matthias W Beckmann; Sebastian Jud; Arif B Ekici; Arndt Hartmann; Alexander Hein; Ruediger Schulz-Wendtland; Barbara Burwinkel; Frederik Marme; Andreas Schneeweiss; Hans-Peter Sinn; Christof Sohn; Sandrine Tchatchou; Stig E Bojesen; Børge G Nordestgaard; Henrik Flyger; David D Ørsted; Diljit Kaur-Knudsen; Roger L Milne; Jose I Arias Pérez; Pilar Zamora; Primitiva Menéndez Rodríguez; Javier Benítez; Hiltrud Brauch; Christina Justenhoven; Yon-Dschun Ko; Ute Hamann; Hans-Peter Fischer; Thomas Brüning; Beate Pesch; Jenny Chang-Claude; Shan Wang-Gohrke; Michael Bremer; Johann H Karstens; Peter Hillemanns; Thilo Dörk; Heli A Nevanlinna; Tuomas Heikkinen; Päivi Heikkilä; Carl Blomqvist; Kristiina Aittomäki; Kirsimari Aaltonen; Annika Lindblom; Sara Margolin; Arto Mannermaa; Veli-Matti Kosma; Jaana M Kauppinen; Vesa Kataja; Päivi Auvinen; Matti Eskelinen; Ylermi Soini; Georgia Chenevix-Trench; Amanda B Spurdle; Jonathan Beesley; Xiaoqing Chen; Helene Holland; Diether Lambrechts; Bart Claes; Thijs Vandorpe; Patrick Neven; Hans Wildiers; Dieter Flesch-Janys; Rebecca Hein; Thomas Löning; Matthew Kosel; Zachary S Fredericksen; Xianshu Wang; Graham G Giles; Laura Baglietto; Gianluca Severi; Catriona McLean; Christopher A Haiman; Brian E Henderson; Loic Le Marchand; Laurence N Kolonel; Grethe Grenaker Alnæs; Vessela Kristensen; Anne-Lise Børresen-Dale; David J Hunter; Susan E Hankinson; Irene L Andrulis; Anna Marie Mulligan; Frances P O'Malley; Peter Devilee; Petra E A Huijts; Rob A E M Tollenaar; Christi J Van Asperen; Caroline S Seynaeve; Stephen J Chanock; Jolanta Lissowska; Louise Brinton; Beata Peplonska; Jonine Figueroa; Xiaohong R Yang; Maartje J Hooning; Antoinette Hollestelle; Rogier A Oldenburg; Agnes Jager; Mieke Kriege; Bahar Ozturk; Geert J L H van Leenders; Per Hall; Kamila Czene; Keith Humphreys; Jianjun Liu; Angela Cox; Daniel Connley; Helen E Cramp; Simon S Cross; Sabapathy P Balasubramanian; Malcolm W R Reed; Alison M Dunning; Douglas F Easton; Manjeet K Humphreys; Carlos Caldas; Fiona Blows; Kristy Driver; Elena Provenzano; Jan Lubinski; Anna Jakubowska; Tomasz Huzarski; Tomasz Byrski; Cezary Cybulski; Bohdan Gorski; Jacek Gronwald; Paul Brennan; Suleeporn Sangrajrang; Valerie Gaborieau; Chen-Yang Shen; Chia-Ni Hsiung; Jyh-Cherng Yu; Shou-Tung Chen; Giu-Cheng Hsu; Ming-Feng Hou; Chiun-Sheng Huang; Hoda Anton-Culver; Argyrios Ziogas; Paul D P Pharoah; Montserrat Garcia-Closas Journal: Hum Mol Genet Date: 2011-05-19 Impact factor: 6.150
Authors: Logan C Walker; Zachary S Fredericksen; Xianshu Wang; Robert Tarrell; Vernon S Pankratz; Noralane M Lindor; Jonathan Beesley; Sue Healey; Xiaoqing Chen; Dominique Stoppa-Lyonnet; Carole Tirapo; Sophie Giraud; Sylvie Mazoyer; Danièle Muller; Jean-Pierre Fricker; Capucine Delnatte; Rita K Schmutzler; Barbara Wappenschmidt; Christoph Engel; Ines Schönbuchner; Helmut Deissler; Alfons Meindl; Frans B Hogervorst; Martijn Verheus; Maartje J Hooning; Ans Mw van den Ouweland; Marcel R Nelen; Margreet Gem Ausems; Cora M Aalfs; Christi J van Asperen; Peter Devilee; Monique M Gerrits; Quinten Waisfisz; Csilla I Szabo; Douglas F Easton; Susan Peock; Margaret Cook; Clare T Oliver; Debra Frost; Patricia Harrington; D Gareth Evans; Fiona Lalloo; Ros Eeles; Louise Izatt; Carol Chu; Rosemarie Davidson; Diana Eccles; Kai-Ren Ong; Jackie Cook; Tim Rebbeck; Katherine L Nathanson; Susan M Domchek; Christian F Singer; Daphne Gschwantler-Kaulich; Anne-Catharina Dressler; Georg Pfeiler; Andrew K Godwin; Tuomas Heikkinen; Heli Nevanlinna; Bjarni A Agnarsson; Maria Adelaide Caligo; Håkan Olsson; Ulf Kristoffersson; Annelie Liljegren; Brita Arver; Per Karlsson; Beatrice Melin; Olga M Sinilnikova; Lesley McGuffog; Antonis C Antoniou; Georgia Chenevix-Trench; Amanda B Spurdle; Fergus J Couch Journal: Breast Cancer Res Date: 2010-11-29 Impact factor: 6.466
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