Literature DB >> 18523652

Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants.

Benjamin E Steinberg1, Sergio Grinstein.   

Abstract

Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome maturation and promote their own survival, and to describe how defective phagosomal lipid metabolism can result in disease.

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Year:  2008        PMID: 18523652      PMCID: PMC2396921          DOI: 10.1172/JCI35433

Source DB:  PubMed          Journal:  J Clin Invest        ISSN: 0021-9738            Impact factor:   14.808


  123 in total

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