| Literature DB >> 18523652 |
Benjamin E Steinberg1, Sergio Grinstein.
Abstract
Phagocytosis is a key component of the innate immune response and of the clearance of apoptotic bodies. Phagosome formation and subsequent maturation require extensive cytoskeletal rearrangement and precisely choreographed vesicular fusion and fission events. The objectives of this review are to highlight the functional importance of lipids in the phagocytic process, to discuss how pathogenic microorganisms can in some cases manipulate host lipid metabolism to either co-opt or disrupt phagosome maturation and promote their own survival, and to describe how defective phagosomal lipid metabolism can result in disease.Entities:
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Year: 2008 PMID: 18523652 PMCID: PMC2396921 DOI: 10.1172/JCI35433
Source DB: PubMed Journal: J Clin Invest ISSN: 0021-9738 Impact factor: 14.808