OBJECTIVE: We report a very rare case of Hoffmann's syndrome with musclehypertrophy complicating hypothyroidism. CLINICAL PRESENTATION: A 24-year-old man presented with a 2-year history of forgetfulness, swelling in his face, shoulder and calf, and motor weakness in his lower extremities. His calf and shoulder muscles were hypertrophic. Neurological examination revealed hoarseness of the voice, proximal muscle weakness, reduced deep tendon reflexes and a mildly ataxic gait. Laboratory tests indicated markedly elevated serum muscle enzymes and lipids, a high thyroid-stimulating hormone level and low free triiodothyronine and free thyroxine levels. Electromyographic evaluation showed myopathy. INTERVENTION: Oral L-thyroxine treatment was started and at a 1-month follow-up examination, mental status and physical performance were improved. CONCLUSION: This report shows that in the differential diagnosis of myopathy with pseudohypertrophy, Hoffmann's syndrome should be considered. (c) 2008 S. Karger AG, Basel
OBJECTIVE: We report a very rare case of Hoffmann's syndrome with musclehypertrophy complicating hypothyroidism. CLINICAL PRESENTATION: A 24-year-old man presented with a 2-year history of forgetfulness, swelling in his face, shoulder and calf, and motor weakness in his lower extremities. His calf and shoulder muscles were hypertrophic. Neurological examination revealed hoarseness of the voice, proximal muscle weakness, reduced deep tendon reflexes and a mildly ataxic gait. Laboratory tests indicated markedly elevated serum muscle enzymes and lipids, a high thyroid-stimulating hormone level and low free triiodothyronine and free thyroxine levels. Electromyographic evaluation showed myopathy. INTERVENTION: Oral L-thyroxine treatment was started and at a 1-month follow-up examination, mental status and physical performance were improved. CONCLUSION: This report shows that in the differential diagnosis of myopathy with pseudohypertrophy, Hoffmann's syndrome should be considered. (c) 2008 S. Karger AG, Basel
Authors: Kang Won Lee; Sun Hwa Kim; Kyoung Jin Kim; Sang Hyun Kim; Hee Young Kim; Byung Jo Kim; Sin Gon Kim; Dong Seop Choi Journal: Endocrinol Metab (Seoul) Date: 2015-09-22
Authors: Nicole M van Veelen; Stefan Fischli; Frank J P Beeres; Timo Eisenhut; Reto Babst; Christoph Henzen; Björn-Christian Link Journal: BMC Endocr Disord Date: 2020-06-05 Impact factor: 2.763