Literature DB >> 18522907

The neuroscientist's melting pot: immunology, cell transplantation and other delivery systems, and enlightenment of disease etiology and treatment.

David J Eve1, Paul R Sanberg.   

Abstract

A snapshot of the current state of play with respect to a number of neurological disease causes and their potential treatments from a cell transplantation perspective, was provided at the 14th annual meeting of American Society for Neural Therapy and Repair (ASNTR). Parkinson's disease and related studies were heavily featured, with Alzheimer's disease, aging and spinal cord injury also proving to be well represented. A number of studies looked at different delivery systems including stem cells or adeno-associated virus vectors, both as proof-of-principles and also their potential as treatments, delivering neurotrophic factors. 'Simple' ways to help battle these disorders, such as dietary modification or supplementation were also revealed. Transplantation was explored both in vivo and in cell culture, where ways to improve cell survival or cause differentiation were investigated. A few reports also shed light on the likelihood of an immune response following transplantation, an important consideration for any potential treatment.

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Year:  2008        PMID: 18522907     DOI: 10.1007/BF03033511

Source DB:  PubMed          Journal:  Neurotox Res        ISSN: 1029-8428            Impact factor:   3.911


  4 in total

1.  Antisense RNA sequences modulating the ataxin-1 message: molecular model of gene therapy for spinocerebellar ataxia type 1, a dominant-acting unstable trinucleotide repeat disease.

Authors:  Youxin Gao; Tao Zu; Walter C Low; Harry T Orr; R Scott McIvor
Journal:  Cell Transplant       Date:  2008       Impact factor: 4.064

2.  Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys.

Authors:  Jorge E Quintero; Brian K Day; Zhiming Zhang; Richard Grondin; Michelle L Stephens; Peter Huettl; François Pomerleau; Don M Gash; Greg A Gerhardt
Journal:  Exp Neurol       Date:  2007-08-22       Impact factor: 5.330

3.  Biocompatibility of PEG-based hydrogels in primate brain.

Authors:  K B Bjugstad; D E Redmond; K J Lampe; D S Kern; J R Sladek; M J Mahoney
Journal:  Cell Transplant       Date:  2008       Impact factor: 4.064

4.  Phenotypic characteristics of hybrid cells produced by cell fusion of porcine adrenal chromaffin cells with human mesenchymal stem cells: a preliminary study.

Authors:  Guangbin Shi; Ke Ma; George D Pappas; Tingyu Qu
Journal:  Neurol Res       Date:  2008-02-04       Impact factor: 2.448

  4 in total

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