| Literature DB >> 18522826 |
Ta-Yuan Chang1, Catherine Chang.
Abstract
Niemann-Pick C1-like 1 (NPC1L1) is a target for ezetimibe, a drug that blocks intestinal cholesterol absorption. A new study by Ge et al. (2008) in this issue of Cell Metabolism shows that non-lipoprotein-bound cholesterol induces endocytosis of NPC1L1 and that ezetimibe blocks the internalization of the NPC1L1/cholesterol complex. The in vivo significance of these findings is discussed.Entities:
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Year: 2008 PMID： 18522826 DOI： 10.1016/j.cmet.2008.05.001
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287