Literature DB >> 18522423

A one-pot coupling/hydrolysis/condensation process to pyrrolo[1,2-a]quinoxaline.

Qiliang Yuan1, Dawei Ma.   

Abstract

CuI/L-proline-catalyzed coupling of 2-halotrifluoroacetanilides with pyrrole-2-carboxylate esters in DMSO at 80-90 degrees C followed by in situ hydrolysis at 60 degrees C afforded pyrrolo[1,2-a]quinoxalines. Indole-2-carboxylate esters underwent the same process smoothly to provide the corresponding tetracyclic products.

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Year:  2008        PMID： 18522423     DOI： 10.1021/jo8008098

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

Authors:  Sarah M Scarry; Kimberly M Lovell; Kevin J Frankowski; Laura M Bohn; Jeffrey Aubé
Journal:  J Org Chem       Date:  2016-08-02       Impact factor: 4.354

2.  Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C-X (X = H or N) bond cleavage.

Authors:  Qiu-Chao Mu; Yi-Xue Nie; Xing-Feng Bai; Jing Chen; Lei Yang; Zheng Xu; Li Li; Chun-Gu Xia; Li-Wen Xu
Journal:  Chem Sci       Date:  2019-08-19       Impact factor: 9.825

3.  A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate.

Authors:  Mohammad Piltan; Loghman Moradi; Golaleh Abasi; Seyed Amir Zarei
Journal:  Beilstein J Org Chem       Date:  2013-03-11       Impact factor: 2.883

4.  First Metal-Free Synthesis of Tetracyclic Pyrido and Pyrazino Thienopyrimidinone Molecules.

Authors:  Mohammed Aounzou; Joana F Campos; Mohammed Loubidi; Sabine Berteina-Raboin
Journal:  Molecules       Date:  2018-05-11       Impact factor: 4.411

5.  Copper-Promoted One-Pot Approach: Synthesis of Benzimidazoles.

Authors:  S N Murthy Boddapati; Ramana Tamminana; Ravi Kumar Gollapudi; Sharmila Nurbasha; Mohamed E Assal; Osamah Alduhaish; Mohammed Rafiq H Siddiqui; Hari Babu Bollikolla; Syed Farooq Adil
Journal:  Molecules       Date:  2020-04-14       Impact factor: 4.411
  5 in total

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