Literature DB >> 18520997

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity.

Zeineb Es-Salah1, Bruno Lapied, Gaëlle Le Goff, Alain Hamon.   

Abstract

A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122) that is close to the putative GABA-binding site. We assessed the functional effects of editing at this site by expressing homomeric RDL receptors in Xenopus oocytes. After replacement of arginine 122 with a glycine, both agonist and fipronil potencies were shifted to the right in either fipronil-sensitive receptors or mutated resistant receptors (A301G/T350M). These data provide the first insight on the influence of RNA editing on GABA receptor function.

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Year:  2008        PMID： 18520997     DOI： 10.1097/WNR.0b013e32830216c7

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  5 in total

1.  Xenopus Oocytes: A Tool to Decipher Molecular Specificity of Insecticides towards Mammalian and Insect GABA-A Receptors.

Authors:  Anaïs Bertaud; Thierry Cens; Rosanna Mary; Matthieu Rousset; Elodie Arel; Jean-Baptiste Thibaud; Michel Vignes; Claudine Ménard; Sébastien Dutertre; Claude Collet; Pierre Charnet
Journal:  Membranes (Basel)       Date:  2022-04-19

2.  Allosteric modulation by benzodiazepines of GABA-gated chloride channels of an identified insect motor neurone.

Authors:  Steven D Buckingham; Yoshiaki Higashino; David B Sattelle
Journal:  Invert Neurosci       Date:  2009-10-22

3.  RNA editing of the GABA(A) receptor alpha3 subunit alters the functional properties of recombinant receptors.

Authors:  Mitchell L Nimmich; Laura S Heidelberg; Janet L Fisher
Journal:  Neurosci Res       Date:  2009-04       Impact factor: 3.304

4.  Cloning, expression analysis, and molecular modeling of the gamma-aminobutyric acid receptor alpha2 subunit gene from the common cutworm, Spodoptera litura.

Authors:  Hongliang Zuo; Lu Gao; Zhen Hu; Haiyuan Liu; Guohua Zhong
Journal:  J Insect Sci       Date:  2013       Impact factor: 1.857

5.  Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes.

Authors:  Kristin Lees; Maria Musgaard; Siros Suwanmanee; Steven David Buckingham; Philip Biggin; David Sattelle
Journal:  PLoS One       Date:  2014-05-13       Impact factor: 3.240
  5 in total

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