Oner Dikensoy1. 1. Department of Pulmonary Diseases, Gaziantep University, Gaziantep, Turkey. dikensoy@yahoo.com
Abstract
PURPOSE OF REVIEW: The prevalence of malignant mesothelioma due to erionite exposure in Central Anatolia is very high. In this report, we review the recent developments on this epidemic on the basis of previous literature. RECENT FINDINGS: Recently, it has been shown that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells. Additionally, long-term exposure to erionite transforms human mesothelial cells in vitro, regardless of the presence of Simian Virus 40 sequences, leading to foci formation in cultured monolayers. It has also been confirmed that a genetic predisposition to erionite carcinogenesis is the cause of the mesothelioma epidemic in Cappadocia. SUMMARY: The data obtained recently on the epidemiology, etiology, and pathogenesis of the mesothelioma due to erionite exposure in Turkey are described.
PURPOSE OF REVIEW: The prevalence of malignant mesothelioma due to erionite exposure in Central Anatolia is very high. In this report, we review the recent developments on this epidemic on the basis of previous literature. RECENT FINDINGS: Recently, it has been shown that erionite is poorly cytotoxic, induces proliferating signals and high growth rate in human mesothelial cells. Additionally, long-term exposure to erionite transforms human mesothelial cells in vitro, regardless of the presence of Simian Virus 40 sequences, leading to foci formation in cultured monolayers. It has also been confirmed that a genetic predisposition to erionite carcinogenesis is the cause of the mesothelioma epidemic in Cappadocia. SUMMARY: The data obtained recently on the epidemiology, etiology, and pathogenesis of the mesothelioma due to erionite exposure in Turkey are described.
Authors: Matthew J Soeberg; Mai Anh Luong; Van Thuan Tran; Anh Thanh Tran; Thị Thu Huyen Nguyen; Dieu Bui; Thi Hoai Nga Nguyen; Ken Takahashi; Nico van Zandwijk Journal: Int J Occup Environ Health Date: 2016-07-08
Authors: Joseph LaDou; Barry Castleman; Arthur Frank; Michael Gochfeld; Morris Greenberg; James Huff; Tushar Kant Joshi; Philip J Landrigan; Richard Lemen; Jonny Myers; Morando Soffritti; Colin L Soskolne; Ken Takahashi; Daniel Teitelbaum; Benedetto Terracini; Andrew Watterson Journal: Environ Health Perspect Date: 2010-06-08 Impact factor: 9.031