| Literature DB >> 18520047 |
Katsuhiko Mikuni1, Katsuyoshi Nakanishi, Koji Hara, Kozo Hara, Wakao Iwatani, Tetsuya Amano, Kosho Nakamura, Yoshinori Tsuchiya, Hiroshi Okumoto, Tadakatsu Mandai.
Abstract
The antitumor activity of newly developed taxoids possessing a sugar moiety (glucose, galactose or mannose) to improve water solubility was evaluated. Galactose-bound taxoid (10-alpha-GAG-DT) proved superior to all other taxoids in both water solubility and antitumor activity. Therapeutic efficacy of 10-alpha-GAG-DT in terms of in vivo antitumor activity was found to be approximately equivalent to that of docetaxel, which is known to be superior to that of paclitaxel. The observation that the sugar moiety was gradually hydrolyzed in serum to release docetaxel indicates that 10-alpha-GAG-DT acts as a prodrug.Entities:
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Year: 2008 PMID： 18520047 DOI： 10.1248/bpb.31.1155
Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233