Literature DB >> 18519720

Cell-penetrating peptide TP10 shows broad-spectrum activity against both Plasmodium falciparum and Trypanosoma brucei brucei.

Romanico B G Arrighi1, Charles Ebikeme, Yang Jiang, Lisa Ranford-Cartwright, Michael P Barrett, Ulo Langel, Ingrid Faye.   

Abstract

Malaria and trypanosomiasis are diseases which afflict millions and for which novel therapies are urgently required. We have tested two well-characterized cell-penetrating peptides (CPPs) for antiparasitic activity. One CPP, designated TP10, has broad-spectrum antiparasitic activity against Plasmodium falciparum, both blood and mosquito stages, and against blood-stage Trypanosoma brucei brucei.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18519720      PMCID： PMC2533502          DOI： 10.1128/AAC.01450-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  33 in total

1.  Deletion analogues of transportan.

Authors:  U Soomets; M Lindgren; X Gallet; M Hällbrink; A Elmquist; L Balaspiri; M Zorko; M Pooga; R Brasseur; U Langel
Journal:  Biochim Biophys Acta       Date:  2000-07-31

Review 2.  Cell-penetrating peptides: mechanism and kinetics of cargo delivery.

Authors:  Matjaz Zorko; Ulo Langel
Journal:  Adv Drug Deliv Rev       Date:  2005-01-22       Impact factor: 15.470

3.  Cell transduction pathways of transportans.

Authors:  Kärt Padari; Pille Säälik; Mats Hansen; Kaida Koppel; Raivo Raid; Ulo Langel; Margus Pooga
Journal:  Bioconjug Chem       Date:  2005 Nov-Dec       Impact factor: 4.774

Review 4.  Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update.

Authors:  Sanjay Kumar; Mithu Guha; Vinay Choubey; Pallab Maity; Uday Bandyopadhyay
Journal:  Life Sci       Date:  2006-11-10       Impact factor: 5.037

5.  Mechanism of the cell-penetrating peptide transportan 10 permeation of lipid bilayers.

Authors:  Lindsay E Yandek; Antje Pokorny; Anders Florén; Kristina Knoelke; Ulo Langel; Paulo F F Almeida
Journal:  Biophys J       Date:  2007-01-11       Impact factor: 4.033

6.  Use of penetrating peptides interacting with PP1/PP2A proteins as a general approach for a drug phosphatase technology.

Authors:  Julien Guergnon; Frédéric Dessauge; Victoria Dominguez; Jean Viallet; Serge Bonnefoy; Victor J Yuste; Odile Mercereau-Puijalon; Xavier Cayla; Angelita Rebollo; Santos A Susin; Pierre-Etienne Bost; Alphonse Garcia
Journal:  Mol Pharmacol       Date:  2005-12-30       Impact factor: 4.436

7.  Activity of an engineered synthetic killer peptide on Leishmania major and Leishmania infantum promastigotes.

Authors:  Dianella Savoia; Sara Scutera; Stefania Raimondo; Stefania Conti; Walter Magliani; Luciano Polonelli
Journal:  Exp Parasitol       Date:  2006-02-17       Impact factor: 2.011

Review 8.  The trypanosomiases.

Authors:  Michael P Barrett; Richard J S Burchmore; August Stich; Julio O Lazzari; Alberto Carlos Frasch; Juan José Cazzulo; Sanjeev Krishna
Journal:  Lancet       Date:  2003-11-01       Impact factor: 79.321

9.  Killing of African trypanosomes by antimicrobial peptides.

Authors:  Bradford S McGwire; Cheryl L Olson; Brian F Tack; David M Engman
Journal:  J Infect Dis       Date:  2003-06-16       Impact factor: 5.226

10.  Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene.

Authors:  Stéphanie Blandin; Luis F Moita; Thomas Köcher; Matthias Wilm; Fotis C Kafatos; Elena A Levashina
Journal:  EMBO Rep       Date:  2002-08-16       Impact factor: 8.807
View more
  16 in total

Review 1.  Antimicrobial peptide killing of African trypanosomes.

Authors:  J M Harrington
Journal:  Parasite Immunol       Date:  2011-08       Impact factor: 2.280

2.  Assessment of SYBR green I dye-based fluorescence assay for screening antimalarial activity of cationic peptides and DNA intercalating agents.

Authors:  Rakesh Bhatia; Ankur Gautam; Shailendra K Gautam; Divya Mehta; Vinod Kumar; Gajendra P S Raghava; Grish C Varshney
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

3.  Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine.

Authors:  Christof Sparr; Nirupam Purkayastha; Beata Kolesinska; Martin Gengenbacher; Borko Amulic; Kai Matuschewski; Dieter Seebach; Faustin Kamena
Journal:  Antimicrob Agents Chemother       Date:  2013-07-15       Impact factor: 5.191

4.  Identification of cell-penetrating peptides that are bactericidal to Neisseria meningitidis and prevent inflammatory responses upon infection.

Authors:  Olaspers Sara Eriksson; Miriam Geörg; Hong Sjölinder; Rannar Sillard; Staffan Lindberg; Ulo Langel; Ann-Beth Jonsson
Journal:  Antimicrob Agents Chemother       Date:  2013-05-20       Impact factor: 5.191

Review 5.  Genetic approaches to interfere with malaria transmission by vector mosquitoes.

Authors:  Sibao Wang; Marcelo Jacobs-Lorena
Journal:  Trends Biotechnol       Date:  2013-02-06       Impact factor: 19.536

6.  Aryl-alkyl-lysines: small molecular membrane-active antiplasmodial agents.

Authors:  Chandradhish Ghosh; Shweta Chaubey; Utpal Tatu; Jayanta Haldar
Journal:  Medchemcomm       Date:  2016-12-16       Impact factor: 3.597

7.  Current developments in the therapy of protozoan infections.

Authors:  Mario Zucca; Dianella Savoia
Journal:  Open Med Chem J       Date:  2011-03-09

Review 8.  Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies.

Authors:  Hua Li; Tung Yu Tsui; Wenxue Ma
Journal:  Int J Mol Sci       Date:  2015-08-18       Impact factor: 5.923

9.  Assessment of anti-plasmodial activity of non-hemolytic, non-immunogenic, non-toxic antimicrobial peptides (AMPs LR14) produced by Lactobacillus plantarum LR/14.

Authors:  Ruchi Gupta; Vinoth Rajendran; Prahlad C Ghosh; Sheela Srivastava
Journal:  Drugs R D       Date:  2014-06

10.  Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium.

Authors:  Victoria Carter; Ann Underhill; Ibrahima Baber; Lakamy Sylla; Mounirou Baby; Isabelle Larget-Thiery; Agnès Zettor; Catherine Bourgouin; Ulo Langel; Ingrid Faye; Laszlo Otvos; John D Wade; Mamadou B Coulibaly; Sekou F Traore; Frederic Tripet; Paul Eggleston; Hilary Hurd
Journal:  PLoS Pathog       Date:  2013-11-21       Impact factor: 6.823
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.