Literature DB >> 1851798

Induction of autoreactive B cells allows priming of autoreactive T cells.

R H Lin1, M J Mamula, J A Hardin, C A Janeway.   

Abstract

A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.

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Year:  1991        PMID： 1851798      PMCID： PMC2190847          DOI： 10.1084/jem.173.6.1433

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  27 in total

Review 1.  T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state.

Authors:  M K Jenkins; D M Pardoll; J Mizuguchi; H Quill; R H Schwartz
Journal:  Immunol Rev       Date:  1987-02       Impact factor: 12.988

Review 2.  B-cell tolerance and autoimmunity.

Authors:  C J Elson; J D Naysmith; R B Taylor
Journal:  Int Rev Exp Pathol       Date:  1979

3.  Induction of red cell autoantibodies in normal mice.

Authors:  J H Playfair; S Marshall-Clarke
Journal:  Nat New Biol       Date:  1973-06-13

4.  Role of antigen-specific B cells in the induction of SRBC-specific T cell proliferation.

Authors:  B A Malynn; H H Wortis
Journal:  J Immunol       Date:  1984-05       Impact factor: 5.422

5.  Infectious immunological tolerance.

Authors:  R K Gershon; K Kondo
Journal:  Immunology       Date:  1971-12       Impact factor: 7.397

6.  A theory of self-nonself discrimination.

Authors:  P Bretscher; M Cohn
Journal:  Science       Date:  1970-09-11       Impact factor: 47.728

7.  Evidence that the Thy-1 molecule is the target for T cell mitogenic antibody against brain-associated antigens.

Authors:  B Jones
Journal:  Eur J Immunol       Date:  1983-08       Impact factor: 5.532

8.  Genetic control of the T-lymphocyte proliferative response to cytochrome c.

Authors:  R H Schwartz; A M Solinger; M Ultee; E Margoliash
Journal:  Adv Exp Med Biol       Date:  1978       Impact factor: 2.622

9.  Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

Authors:  E A Lerner; M R Lerner; C A Janeway; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

10.  Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies.

Authors:  R Reuter; R Lührmann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205
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  74 in total

1.  Antigen presentation of Type II collagen in rats.

Authors:  B Catchpole; N A Staines; A S Hamblin
Journal:  Clin Exp Immunol       Date:  2001-09       Impact factor: 4.330

2.  CD4(+) T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis.

Authors:  Jean Wu; John Hicks; Jason Borillo; William F Glass; Ya-Huan Lou
Journal:  J Clin Invest       Date:  2002-02       Impact factor: 14.808

3.  B-cell repertoire specific for an unfolded self-determinant of mouse lysozyme escape tolerance and dominantly participate in the autoantibody response.

Authors:  Yoshiyuki Tsujihata; Yousuke Mizukami; Tadashi Ueda; Takanori So; Taiji Imoto
Journal:  Immunology       Date:  2002-12       Impact factor: 7.397

Review 4.  Treating human autoimmune disease by depleting B cells.

Authors:  R J Looney
Journal:  Ann Rheum Dis       Date:  2002-10       Impact factor: 19.103

Review 5.  Autoantibodies against small cytoplasmic ribonucleoproteins: the anti-Ro/SS-A and anti-La/SS-B autoimmune response. A review of autoantibody detection, autoantigen composition, autoantibody-disease associations and possible etiologic mechanisms.

Authors:  J F Meilof
Journal:  Rheumatol Int       Date:  1992       Impact factor: 2.631

Review 6.  The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus.

Authors:  R Merino; L Fossati; S Izui
Journal:  Springer Semin Immunopathol       Date:  1992

7.  Presentation of the candidate rheumatoid arthritis autoantigen aggrecan by antigen-specific B cells induces enhanced CD4(+) T helper type 1 subset differentiation.

Authors:  Caroline L Wilson; Dominic W Hine; Ariel Pradipta; Jeffrey P Pearson; Willem van Eden; John H Robinson; Andrew M Knight
Journal:  Immunology       Date:  2012-04       Impact factor: 7.397

Review 8.  Cancer and scleroderma: a paraneoplastic disease with implications for malignancy screening.

Authors:  Ami A Shah; Livia Casciola-Rosen
Journal:  Curr Opin Rheumatol       Date:  2015-11       Impact factor: 5.006

Review 9.  Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities.

Authors:  Ahmad Zaheen; Alberto Martin
Journal:  Am J Pathol       Date:  2011-02       Impact factor: 4.307

Review 10.  Autoantibody-dependent and autoantibody-independent roles for B cells in systemic lupus erythematosus: past, present, and future.

Authors:  Noam Jacob; William Stohl
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815
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