Literature DB >> 1851765

Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM.

J S Williamson1, K C Sykes, S A Stohlman.   

Abstract

The eradication of infectious virus from the central nervous system (CNS) following infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) is thought to be immune-mediated. Furthermore, a significant decrease of infectious virus coincides with the appearance of prominent inflammatory infiltrates in the brain and spinal cord. In the present study, mononuclear cells infiltrating the brain during JHMV infection were isolated and characterized. While all subsets of immune cells were present, there appeared to be a temporal relationship between the peak incidence of CD8+ T cells (40% of total isolated cells) and reduction of virus at day 7 post-infection. Cells with the natural killer (NK) phenotype (at least 30%) were also present throughout infection. These data suggest that CD8+ T cells and NK cells are prominent among cells which infiltrate the brain during JHM virus infection and may have important roles in reduction of virus within the CNS.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1851765      PMCID： PMC7119758          DOI： 10.1016/0165-5728(91)90189-e

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  26 in total

1.  Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system.

Authors:  M B Oldstone; P Blount; P J Southern; P W Lampert
Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

2.  Pathogenesis of demyelination induced by a mouse hepatitis.

Authors:  L P Weiner
Journal:  Arch Neurol       Date:  1973-05

3.  Ganglio-N-tetraosylceramide (asialo GM1), an antigen common to the brain and immune system: its localization in myelin.

Authors:  S Kusunoki; S Tsuji; Y Nagai
Journal:  Brain Res       Date:  1985-05-13       Impact factor: 3.252

4.  Protective effect of monoclonal antibodies on lethal mouse hepatitis virus infection in mice.

Authors:  K Nakanaga; K Yamanouchi; K Fujiwara
Journal:  J Virol       Date:  1986-07       Impact factor: 5.103

5.  Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity.

Authors:  D D Skias; D K Kim; A T Reder; J P Antel; D W Lancki; F W Fitch
Journal:  J Immunol       Date:  1987-05-15       Impact factor: 5.422

6.  Murine coronaviruses: isolation and characterization of two plaque morphology variants of the JHM neurotropic strain.

Authors:  S A Stohlman; P R Brayton; J O Fleming; L P Weiner; M M Lai
Journal:  J Gen Virol       Date:  1982-12       Impact factor: 3.891

7.  Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody.

Authors:  M J Buchmeier; H A Lewicki; P J Talbot; R L Knobler
Journal:  Virology       Date:  1984-01-30       Impact factor: 3.616

8.  Natural killer cell activity during mouse hepatitis virus infection: response in the absence of interferon.

Authors:  S A Stohlman; P R Brayton; R C Harmon; D Stevenson; R G Ganges; G K Matsushima
Journal:  Int J Cancer       Date:  1983-03-15       Impact factor: 7.396

9.  Reactivity of anti-asialo GM1 serum with tumoricidal and non-tumoricidal mouse macrophages.

Authors:  R H Wiltrout; A Santoni; E S Peterson; D C Knott; W R Overton; R B Herberman; H T Holden
Journal:  J Leukoc Biol       Date:  1985-05       Impact factor: 4.962

10.  Monoclonal antibodies to the matrix (E1) glycoprotein of mouse hepatitis virus protect mice from encephalitis.

Authors:  J O Fleming; R A Shubin; M A Sussman; N Casteel; S A Stohlman
Journal:  Virology       Date:  1989-01       Impact factor: 3.616
View more
  35 in total

1.  Cytotoxic T-cell-resistant variants arise at early times after infection in C57BL/6 but not in SCID mice infected with a neurotropic coronavirus.

Authors:  L Pewe; S Xue; S Perlman
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

2.  Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.

Authors:  M T Lin; S A Stohlman; D R Hinton
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

Review 3.  Cell replacement therapies to promote remyelination in a viral model of demyelination.

Authors:  Emanuele Tirotta; Kevin S Carbajal; Chris S Schaumburg; Lucia Whitman; Thomas E Lane
Journal:  J Neuroimmunol       Date:  2010-06-02       Impact factor: 3.478

4.  Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

Authors:  Nadine De Albuquerque; Ehtesham Baig; Xuezhong Ma; Jianhua Zhang; William He; Andrea Rowe; Marlena Habal; Mingfeng Liu; Itay Shalev; Gregory P Downey; Reginald Gorczynski; Jagdish Butany; Julian Leibowitz; Susan R Weiss; Ian D McGilvray; M James Phillips; Eleanor N Fish; Gary A Levy
Journal:  J Virol       Date:  2006-11       Impact factor: 5.103

5.  Yellow fever virus encephalitis: properties of the brain-associated T-cell response during virus clearance in normal and gamma interferon-deficient mice and requirement for CD4+ lymphocytes.

Authors:  T Liu; T J Chambers
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

6.  Characterization of mouse hepatitis virus-specific cytotoxic T cells derived from the central nervous system of mice infected with the JHM strain.

Authors:  S A Stohlman; S Kyuwa; J M Polo; D Brady; M M Lai; C C Bergmann
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

7.  NKG2D receptor signaling enhances cytolytic activity by virus-specific CD8+ T cells: evidence for a protective role in virus-induced encephalitis.

Authors:  Kevin B Walsh; Lewis L Lanier; Thomas E Lane
Journal:  J Virol       Date:  2007-12-26       Impact factor: 5.103

8.  Characterization of the Ld-restricted cytotoxic T-lymphocyte epitope in the mouse hepatitis virus nucleocapsid protein.

Authors:  C Bergmann; M McMillan; S Stohlman
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

9.  Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape mutants.

Authors:  Ming Ming Chua; Katherine C MacNamara; Lani San Mateo; Hao Shen; Susan R Weiss
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

10.  Protective and pathologic roles of the immune response to mouse hepatitis virus type 1: implications for severe acute respiratory syndrome.

Authors:  Aaruni Khanolkar; Stacey M Hartwig; Brayton A Haag; David K Meyerholz; Lecia L Epping; Jodie S Haring; Steven M Varga; John T Harty
Journal:  J Virol       Date:  2009-07-01       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.