Literature DB >> 18516570

Determination of lipolysis in isolated primary adipocytes.

Srikant Viswanadha1, Constantine Londos.   

Abstract

Lipolysis involves the sequential breakdown of triglycerides into free fatty acids and glycerol. The extent of lipolysis is therefore a key determinant of the energy status of an individual and also dictates insulin resistance. Here, we describe a protocol for estimating lipolysis in murine adipocytes. Glycerol released during the lipolytic reaction is estimated radiometrically to determine the extent of lipolysis within the cell and the data are normalized to cell number.

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Year:  2008        PMID： 18516570     DOI： 10.1007/978-1-59745-245-8_22

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  12 in total

1.  Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity.

Authors:  Sarah Navina; Chathur Acharya; James P DeLany; Lidiya S Orlichenko; Catherine J Baty; Sruti S Shiva; Chandra Durgampudi; Jenny M Karlsson; Kenneth Lee; Kyongtae T Bae; Alessandro Furlan; Jaideep Behari; Shiguang Liu; Teresa McHale; Larry Nichols; Georgios Ioannis Papachristou; Dhiraj Yadav; Vijay P Singh
Journal:  Sci Transl Med       Date:  2011-11-02       Impact factor: 17.956

2.  Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1-Dependent Manner.

Authors:  Ajeetha Josephrajan; Ann V Hertzel; Ellie K Bohm; Michael W McBurney; Shin-Ichiro Imai; Douglas G Mashek; Do-Hyung Kim; David A Bernlohr
Journal:  Diabetes       Date:  2019-06-06       Impact factor: 9.461

3.  Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Authors:  Zhao Zhang; Emre Turer; Xiaohong Li; Xiaoming Zhan; Mihwa Choi; Miao Tang; Amanda Press; Steven R Smith; Adeline Divoux; Eva Marie Y Moresco; Bruce Beutler
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-05       Impact factor: 11.205

4.  Nedd4 haploinsufficient mice display moderate insulin resistance, enhanced lipolysis, and protection against high-fat diet-induced obesity.

Authors:  Jing Jing Li; Robert J Ferry; Shiyong Diao; Bingzhong Xue; Suleiman W Bahouth; Francesca-Fang Liao
Journal:  Endocrinology       Date:  2015-01-21       Impact factor: 4.736

5.  Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea.

Authors:  Martin Weiszenstein; Larissa A Shimoda; Michal Koc; Ondrej Seda; Jan Polak
Journal:  Am J Respir Cell Mol Biol       Date:  2016-08       Impact factor: 6.914

Review 6.  Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection.

Authors:  Carole Sztalryd; Alan R Kimmel
Journal:  Biochimie       Date:  2013-09-13       Impact factor: 4.079

Review 7.  Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.

Authors:  Alan R Kimmel; Carole Sztalryd
Journal:  Curr Opin Lipidol       Date:  2014-04       Impact factor: 4.776

8.  Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity.

Authors:  Victoria L B Nelson; Ya-Ping Jiang; Kathleen G Dickman; Lisa M Ballou; Richard Z Lin
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-04-01       Impact factor: 4.310

9.  Adiponectin inhibits lipolysis in mouse adipocytes.

Authors:  Liping Qiao; Brice Kinney; Jerome Schaack; Jianhua Shao
Journal:  Diabetes       Date:  2011-03-23       Impact factor: 9.461

10.  Tissue-specific disruption of Kbtbd2 uncovers adipocyte-intrinsic and -extrinsic features of the teeny lipodystrophy syndrome.

Authors:  Zhao Zhang; Thomas Gallagher; Philipp E Scherer; Bruce Beutler
Journal:  Proc Natl Acad Sci U S A       Date:  2020-05-07       Impact factor: 11.205
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