Literature DB >> 18516454

Surgical treatment of Chagas megacolon. Critical analysis of outcome in operative methods.

Ricardo Luiz Santos Garcia1, Bruna Meyer R de Matos, Omar Féres, José Joaquim Ribeiro da Rocha.   

Abstract

PURPOSE: Surgical treatment of chagasic megacolon has suffered innumerable transformations over the years. Poor knowledge of the disease physiopathology is one of the reasons.
METHODS: From January 1977 to December 2003, 430 patients were submitted to surgical treatment for chagasic megacolon. Of these procedures, 351 were elective and 79 emergency operations carried out at the University Hospital of Ribeirão Preto. Four elective operations, most frequently used, should be singled out: anterior rectosigmoidectomy (52.71%), left hemicolectomy (18.23%), Duhamel-Haddad operation(15.95%), and total colectomy (5.98%). From the 79 exploratory laparotomies performed on an emergency basis, 53 (67.09%) required intestinal resection. From the 430 patients operated upon, 268 (62.33%) progressed without recurrence of intestinal constipation, and 71 (15.51%) had a recurrence. RESULTS AND DISCUSSION: Based on the data collected, left hemicolectomy had the highest constipation recurrence rate compared to other operating procedures; anterior retosigmoidectomy had less complication episodes and a larger recurrence of intestinal constipation in comparison to the Duhamel-Haddad operation. Emergency operations, mainly for the treatment of volvulus and fecaloma, presented high morbidity and mortality and required extensive intestinal resections, stomas and reoperations.

Entities:  

Mesh:

Year:  2008        PMID: 18516454     DOI: 10.1590/s0102-86502008000700015

Source DB:  PubMed          Journal:  Acta Cir Bras        ISSN: 0102-8650            Impact factor:   1.388


  5 in total

Review 1.  Chagas heart disease: report on recent developments.

Authors:  Fabiana S Machado; Linda A Jelicks; Louis V Kirchhoff; Jamshid Shirani; Fnu Nagajyothi; Shankar Mukherjee; Randin Nelson; Christina M Coyle; David C Spray; Antonio C Campos de Carvalho; Fangxia Guan; Cibele M Prado; Michael P Lisanti; Louis M Weiss; Susan P Montgomery; Herbert B Tanowitz
Journal:  Cardiol Rev       Date:  2012 Mar-Apr       Impact factor: 2.644

2.  Would selenium supplementation aid in therapy for Chagas disease?

Authors:  Linda A Jelicks; Andréa P de Souza; Tania C Araújo-Jorge; Herbert B Tanowitz
Journal:  Trends Parasitol       Date:  2011-01-04

3.  Lineage analysis of circulating Trypanosoma cruzi parasites and their association with clinical forms of Chagas disease in Bolivia.

Authors:  Ramona del Puerto; Juan Eiki Nishizawa; Mihoko Kikuchi; Naomi Iihoshi; Yelin Roca; Cinthia Avilas; Alberto Gianella; Javier Lora; Freddy Udalrico Gutierrez Velarde; Luis Alberto Renjel; Sachio Miura; Hiroo Higo; Norihiro Komiya; Koji Maemura; Kenji Hirayama
Journal:  PLoS Negl Trop Dis       Date:  2010-05-18

Review 4.  The chronic gastrointestinal manifestations of Chagas disease.

Authors:  Nilce Mitiko Matsuda; Steven M Miller; Paulo R Barbosa Evora
Journal:  Clinics (Sao Paulo)       Date:  2009       Impact factor: 2.365

Review 5.  Challenges in Chagas Disease Drug Development.

Authors:  Amanda F Francisco; Shiromani Jayawardhana; Francisco Olmo; Michael D Lewis; Shane R Wilkinson; Martin C Taylor; John M Kelly
Journal:  Molecules       Date:  2020-06-17       Impact factor: 4.411

  5 in total

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