Literature DB >> 18516245

Brain Glucose Metabolism Controls Hepatic Glucose and Lipid Production.

Tony K T Lam1.   

Abstract

Brain glucose-sensing mechanisms are implicated in the regulation of feeding behavior and hypoglycemic-induced hormonal counter-regulation. This commentary discusses recent findings indicating that the brain senses glucose to regulate both hepatic glucose and lipid production.

Entities:  

Year:  2007        PMID： 18516245      PMCID： PMC2405765     

Source DB:  PubMed          Journal:  Cellscience        ISSN： 1742-8130


  34 in total

1.  Central administration of oleic acid inhibits glucose production and food intake.

Authors:  Silvana Obici; Zhaohui Feng; Kimyata Morgan; Daniel Stein; George Karkanias; Luciano Rossetti
Journal:  Diabetes       Date:  2002-02       Impact factor: 9.461

2.  The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity.

Authors:  Roberto Coppari; Masumi Ichinose; Charlotte E Lee; Abigail E Pullen; Christopher D Kenny; Robert A McGovern; Vinsee Tang; Shun M Liu; Thomas Ludwig; Streamson C Chua; Bradford B Lowell; Joel K Elmquist
Journal:  Cell Metab       Date:  2005-01       Impact factor: 27.287

3.  Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins.

Authors:  Tony K T Lam; Roger Gutierrez-Juarez; Alessandro Pocai; Sanjay Bhanot; Patrick Tso; Gary J Schwartz; Luciano Rossetti
Journal:  Nat Med       Date:  2007-02-04       Impact factor: 53.440

4.  Brain lactate uptake increases at the site of impact after traumatic brain injury.

Authors:  T Chen; Y Z Qian; A Rice; J P Zhu; X Di; R Bullock
Journal:  Brain Res       Date:  2000-04-10       Impact factor: 3.252

5.  Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation.

Authors:  Monica A Borg; William V Tamborlane; Gerald I Shulman; Robert S Sherwin
Journal:  Diabetes       Date:  2003-03       Impact factor: 9.461

6.  Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.

Authors:  L Pellerin; P J Magistretti
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

7.  Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release.

Authors:  W P Borg; R S Sherwin; M J During; M A Borg; G I Shulman
Journal:  Diabetes       Date:  1995-02       Impact factor: 9.461

Review 8.  Energy substrates for neurons during neural activity: a critical review of the astrocyte-neuron lactate shuttle hypothesis.

Authors:  Ching-Ping Chih; Eugene L Roberts
Journal:  J Cereb Blood Flow Metab       Date:  2003-11       Impact factor: 6.200

9.  Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle.

Authors:  G A Brooks; H Dubouchaud; M Brown; J P Sicurello; C E Butz
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205

Review 10.  Obesity wars: molecular progress confronts an expanding epidemic.

Authors:  Jeffrey S Flier
Journal:  Cell       Date:  2004-01-23       Impact factor: 41.582
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  1 in total

1.  Portal glucose infusion-glucose clamp measures hepatic influence on postprandial systemic glucose appearance as well as whole body glucose disposal.

Authors:  Dan Zheng; Viorica Ionut; Vahe Mooradian; Darko Stefanovski; Richard N Bergman
Journal:  Am J Physiol Endocrinol Metab       Date:  2009-11-24       Impact factor: 4.310
  1 in total

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