| Literature DB >> 18516035 |
Jian Zhou1, Wanlu Du, Kechun Zhou, Yilin Tai, Hailan Yao, Yichang Jia, Yuqiang Ding, Yizheng Wang.
Abstract
The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their roles in brain are largely unknown. Here we report that TRPC6 was localized to excitatory synapses and promoted their formation via a CaMKIV-CREB-dependent pathway. TRPC6 transgenic mice showed enhancement in spine formation, and spatial learning and memory in Morris water maze. These results reveal a previously unknown role of TRPC6 in synaptic and behavioral plasticity.Entities:
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Year: 2008 PMID： 18516035 DOI： 10.1038/nn.2127
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884