BACKGROUND: The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. AIMS: To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. METHOD: Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patients with first-episode schizophrenia-spectrum disorders, 86 patients with established schizophrenia and 55 healthy participants. RESULTS: There were no significant differences in total area across groups. Reductions in callosal width were seen in the region of the anterior genu in first-episode disorder (P<0.005). Similar reductions were seen in the chronic schizophrenia group in the anterior genu, but also in the posterior genu and isthmus (P=0.0005). CONCLUSIONS: Reductions in anterior callosal regions connecting frontal cortex are present at the onset of schizophrenia, and in established illness are accompanied by changes in other regions of the callosum connecting cingulate, temporal and parietal cortices.
BACKGROUND: The shape of the corpus callosum may differ in schizophrenia, although no study has compared first-episode with established illness. AIMS: To investigate the size and shape of the corpus callosum in a large sample of people with first-episode and established schizophrenia. METHOD: Callosal size and shape were determined using high-resolution magnetic resonance imaging on 76 patients with first-episode schizophrenia-spectrum disorders, 86 patients with established schizophrenia and 55 healthy participants. RESULTS: There were no significant differences in total area across groups. Reductions in callosal width were seen in the region of the anterior genu in first-episode disorder (P<0.005). Similar reductions were seen in the chronic schizophrenia group in the anterior genu, but also in the posterior genu and isthmus (P=0.0005). CONCLUSIONS: Reductions in anterior callosal regions connecting frontal cortex are present at the onset of schizophrenia, and in established illness are accompanied by changes in other regions of the callosum connecting cingulate, temporal and parietal cortices.
Authors: Thomas J Whitford; Peter Savadjiev; Marek Kubicki; Lauren J O'Donnell; Douglas P Terry; Sylvain Bouix; Carl-Fredrik Westin; Jason S Schneiderman; Laurel Bobrow; Andrew C Rausch; Margaret Niznikiewicz; Paul G Nestor; Christos Pantelis; Stephen J Wood; Robert W McCarley; Martha E Shenton Journal: Schizophr Res Date: 2011-08-09 Impact factor: 4.939
Authors: Andrew Zalesky; Alex Fornito; Marc L Seal; Luca Cocchi; Carl-Fredrik Westin; Edward T Bullmore; Gary F Egan; Christos Pantelis Journal: Biol Psychiatry Date: 2010-10-29 Impact factor: 13.382
Authors: Christopher L Adamson; Amanda G Wood; Jian Chen; Sarah Barton; David C Reutens; Christos Pantelis; Dennis Velakoulis; Mark Walterfang Journal: Hum Brain Mapp Date: 2011-02-08 Impact factor: 5.038
Authors: Emily C Balevich; M Mehmet Haznedar; Eugene Wang; Randall E Newmark; Rachel Bloom; Jason S Schneiderman; Jonathan Aronowitz; Cheuk Y Tang; King-Wai Chu; William Byne; Monte S Buchsbaum; Erin A Hazlett Journal: Psychiatry Res Date: 2015-01-08 Impact factor: 3.222
Authors: Ralf Tepest; Christopher J Schwarzbach; Barbara Krug; Joachim Klosterkötter; Stephan Ruhrmann; Kai Vogeley Journal: Eur Arch Psychiatry Clin Neurosci Date: 2012-07-21 Impact factor: 5.270
Authors: S M Cotton; K M Filia; A Ratheesh; K Pennell; S Goldstone; P D McGorry Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2016-01 Impact factor: 4.328
Authors: Serge A Mitelman; Yekaterina K Nikiforova; Emily L Canfield; Erin A Hazlett; Adam M Brickman; Lina Shihabuddin; Monte S Buchsbaum Journal: Schizophr Res Date: 2009-08-26 Impact factor: 4.939